Escherichia coli K-12: A cooperatively developed annotation snapshot - 2005

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  • The goal of this group project has been to coordinate and bring up-to-date information on all genes of Escherichia coli K-12. Annotation of the genome of an organism entails identification of genes, the boundaries of genes in terms of precise start and end sites, and description of the gene products. Known and predicted functions were assigned to each gene product on the basis of experimental evidence or sequence analysis. Since both kinds of evidence are constantly expanding, no annotation is complete at any moment in time. This is a snapshot analysis based on the most recent genome sequences of two E.coli K-12 bacteria.An accurate and up-to-date description of E.coli K-12 genes is of particular importance to the scientific community because experimentally determined properties of its gene products provide fundamental information for annotation of innumerable genes of other organisms. Availability of the complete genome sequence of two K-12 strains allows comparison of their genotypes and mutant status of alleles.

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    Article (Published)
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    © The Author 2006. Published by Oxford University Press. All rights reserved. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact
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    • M Riley, T Abe, MB Arnaud, MK Berlyn, FR Blattner, RR Chaudhuri, JD Glasner, T Horiuchi, IM Keseler, T Kosuge, H Nori, NT Pernas, G Plunkett, KE Rudd, MH Serres, GH Thomas, NR Thomson, DS Wishart and BL Wanner. "Escherichia coli K-12: A cooperatively developed annotation snapshot - 2005." Nucleic Acids Research 34 (2006): 1-9. DOI: 10.1093/nar/gkj405