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Skip to Search Results- 53Graduate and Postdoctoral Studies (GPS), Faculty of
- 53Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 36Biological Sciences, Department of
- 36Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 12Chemistry, Department of
- 12Chemistry, Department of/Journal Articles (Chemistry)
- 65Article (Published)
- 53Thesis
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Spring 2022
The DNA damage response (DDR) is critical for maintaining genomic integrity and prevention of genotoxic consequences leading to carcinogenesis. The DDR signaling cascade results either in the activation of the repair pathway, or initiation of apoptosis if the repair is not possible. Many...
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Fall 2013
Ortiz Sandoval, Carolina Guadalupe
The ER mitochondria-associated membrane (MAM) is a hub for many calcium-mediated processes required for cell survival, including apoptosis, autophagy, and ATP production. In this thesis, we identified and characterized the interaction between MAM-enriched Rab32 and its effector Drp1, a master...
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ReAS: Recovery of Ancestral Sequences for Transposable Elements from the Unassembled Reads of a Whole Genome Shotgun
Download2005
Ye, C., Wang, J., Li, S., Li, R., Wong, G.K.S., Ye, J., Yang, H., Han, Y., Yu, J.
We describe an algorithm, ReAS, to recover ancestral sequences for transposable elements (TEs) from the unassembled reads of a whole genome shotgun. The main assumptions are that these TEs must exist at high copy numbers across the genome and must not be so old that they are no longer...
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Resonance Raman Intensities Demonstrate that C5 Substituents Affect the Initial Excited-state Structural Dynamics of Uracil More than C6 Substituents
Download2016-01-01
Teimoory, Faranak, Loppnow, Glen R.
Resonance Raman derived initial excited‐state structural dynamics provide insight into the photochemical mechanisms of pyrimidine nucleobases, in which the photochemistry appears to be dictated by the C5 and C6 substituents. The absorption and resonance Raman spectra and excitation profiles of...
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Respiration, Acid/Base, Ammonia and Ionoregulatory Strategies in the Pacific hagfish (Eptatretus stoutii)
DownloadFall 2016
Hagfish feed on putrefied carrion, which poses several environmental challenges to the scavenger including hypoxia (Low PO2), hypercapnia (high PCO2) and high environmental ammonia (HEA). To any other organism, these conditions would be physiologically challenging; however, hagfish seem to have...
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Roger Saylor and Michel Ferrari (eds): Epistemology and Science Education: Understanding the Evolution vsntelligent Design Controversy
Download2012
Introduction: For decades the creationist movement has threatened the teaching of evolution in the United States, even in public schools. Similar worrisome trends have started in other Western countries. Beyond the major importance of reacting to attempts to undermine the proper teaching of...
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Screening anti-cancer drugs against tubulin using catch-and-release electrospray ionization mass spectrometry
Download2016
Kitova, Elena N., Klassen, John S., Winter, Philip, Tuszynski, Jack A., Darestani, Reza R.
Tubulin, which is the building block of microtubules, plays an important role in cell division. This critical role makes tubulin an attractive target for the development of chemotherapeutic drugs to treat cancer. Currently, there is no general binding assay for tubulin–drug interactions. The...
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Screening anti-cancer drugs against tubulin using catch-and-release electrospray ionization mass spectrometry
Download2016
Kitova, Elena N., Klassen, John S., Winter, Philip, Tuszynski, Jack A., Darestani, Reza R.
Tubulin, which is the building block of microtubules, plays an important role in cell division. This critical role makes tubulin an attractive target for the development of chemotherapeutic drugs to treat cancer. Currently, there is no general binding assay for tubulin–drug interactions. The...
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Screening oligosaccharide libraries against lectins using the proxy protein electrospray ionization mass spectrometry assay
Download2016
Kitova, Elena N., Klassen, John S., Fan, Xuxin, Privé, Gilbert G., Cairo, Christopher W., Xiong, Zi Jian, Ng, Kenneth K. S., Zou, Chunxia, Eugenio, Luiz, Li, Jun
An electrospray ionization mass spectrometry (ESI-MS) assay for screening carbohydrate libraries against lectins is described. The assay is based on the proxy protein ESI-MS method, which combines direct ESI-MS protein–ligand binding measurements and competitive protein binding, to simultaneously...