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Skip to Search Results- 14Loppnow, Glen R.
- 5El-Yazbi, Amira F.
- 2Nair, Sindhu G.
- 2Shoute, Lian C. T.
- 2Teimoory, Faranak
- 1Azimi, Shakiba
- 3DNA Damage
- 2Absorption Spectroscopy
- 2Fluorescence
- 1Anticancer Agents
- 1Antiviral Agents
- 1Base Sequence
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1989-01-01
Loppnow, Glen R., Mathies, Richard A.
A 77‐K cold stage has been developed for spectroscopic measurements in an optical microscope. This stage eliminates fogging of the optical windows observed in an earlier design by adding vacuum jackets around the liquid nitrogen transfer lines and by maximizing the sample‐to‐environment distance...
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2017-01-01
El-Yazbi, Amira F., Wong, Alysha, Loppnow, Glen R.
The human genome is susceptible to change; base mismatches can arise from damaged DNA, replication errors, and spontaneous mutation, and have the potential to cause apoptosis, carcinogenesis, and mutagenesis. Many techniques have been developed for DNA mismatch detection, but many of these...
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1998-01-01
Mitambo, Mitambo M., Zhang, Shuliang L., Loppnow, Glen R.
A novel four nuclear magnetic resonance (NMR)-tube holder is described for quantitative Raman and resonance Raman spectroscopy. This cell has advantages over other divided cell designs in producing high precision quantitation and eliminating off-axis errors. Raman spectra were obtained for both...
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2013-01-01
El-Yazbi, Amira F., Loppnow, Glen R.
Absorption of UV light by nucleic acids can result in the formation of molecular lesions in DNA and RNA, leading to mutagenesis, carcinogenesis, and cell death. In this work, hairpin oligonucleotide probes, which have previously been shown to be selective for DNA damage, are used. The hypochromic...
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2018-01-01
Shoute, Lian C. T., Loppnow, Glen R.
Understanding the dsDNA·EG binding interaction is important because the EvaGreen (EG) dye is increasingly used in real-time quantitative polymerase chain reaction, high resolution melting analysis, and routine quantification of DNA. In this work, a binding isotherm for the interactions of EG with...
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2019-01-01
Nair, Sindhu G., Loppnow, Glen R.
It has been well established that mutations in K-Ras and N-Ras proto-oncogenes can convert them into active oncogenes. Current molecular cancer research has been focused on determining the key steps by which cellular genes become oncogenes and not on the underlying and fundamental chemical damage...
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2014-01-01
El-Yazbi, Amira F., Loppnow, Glen R.
Nucleic acids (NAs) play a vital role in numerous biological processes. Absorption of ultraviolet (UV) light by NAs can result in DNA damage at the molecular level, leading to mutagenesis, carcinogenesis, and cell death. Thus, much effort has been focused on developing methods for detecting...
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Excited-state Dynamics of Alizarin-Sensitized TiO2 Nanoparticles from Resonance Raman Spectroscopy
Download2002-01-01
Shoute, Lian C. T., Loppnow, Glen R.
Resonance Raman spectra of alizarin-sensitized TiO2 nanoparticles have been obtained at excitation wavelengths throughout the 488-nm charge transfer absorption band. The resonance Raman spectrum of the alizarin-sensitized TiO2 nanoparticle is significantly different from the spectrum of free...
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2018-01-01
Dempster, Steve P., Sasidharanpillai, Swaroop, Loppnow, Glen R.
The effect of the N1 ribose sugar on the initial excited‐state structural dynamics of uridine is explored with ultraviolet resonance Raman spectroscopy. Excited‐state slopes and broadening parameters were obtained by simulating the resonance Raman excitation profiles and absorption spectrum using...
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Isolation of RNA from a mixture and its detection by utilizing a microgel-based optical device
Download2018-01-01
Islam, Molla R., Azimi, Shakiba, Teimoory, Faranak, Loppnow, Glen R., Serpe, Michael J.
In this investigation, we show that RNA can be separated from a solution containing DNA and RNA and the isolated RNA can be detected using poly (N-isopropylacrylamide-co-N-(3-aminopropyl) methacrylamide hydrochloride) microgel-based optical devices (etalons). The isolation of RNA was accomplished...