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Skip to Search Results- 1Abdualla, Radya Y
- 1Aghamohammadi Sereshki, Arash
- 1Alaazi, Dominic A
- 1Bhullar, Khushwant Singh
- 1Brotto,Andrew R
- 1Caballero, Hebert S
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NSAID Prodrugs with Improved Anti-inflammatory Activity and Low Ulcerogenicity: Wake Up Call to Pharmaceutical Companies and Health Authorities
DownloadSpring 2012
The objective of this work was to synthesize and evaluate the biological properties of a new series of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) possessing a tyrosol linker between the carboxylic acid present in classical NSAIDs and a NO-releasing group (PROLI/NO)...
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Older Adults and Generativity: Developmental, Experimental, and Clinical Advances in Terror Management Theory
DownloadSpring 2013
Terror Management Theory (TMT) (Greenberg, Pyszczynski, & Solomon, 1986) offers an empirical framework to explore how human beings function despite their fear of death. TMT studies have shown that in order to buffer death anxiety, people strive to meet the standards of their cultural worldview. ...
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Fall 2017
Narratives of King Solomon’s life and reign are preserved in both the Book of Kings and the Book of Chronicles, and both texts contain similar narrative elements and mnemonic constructions, such as Solomon’s role as Temple builder and his great wisdom. Other elements of the narrative have been...
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Role of Caregiver Beliefs About Alzheimer Disease in the Social Creation of Dependency Among Persons With Alzheimer Disease
DownloadFall 2012
It is estimated that over 1.1 million people in Canada will have dementia by 2038 (Alzheimer Society of Canada, 2010). In the caregiving context it is important that independence be maintained for as long as possible. Previous research has shown that caregivers can inadvertently create excess...
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Selected Health Factors (Pulse Pressure, Type 2 Diabetes) and Genetic Polymorphisms (ApoE, IDE rs6583817) Play Independent and Interactive Roles in Patterns of Cognitive Performance and Change in Older Adults
DownloadSpring 2014
Objective: This gene x environment (health) dissertation focused on concurrent and longitudinal change in performance on executive function (EF) and declarative memory (DM) latent variables by normal aging adults. Specifically, we report three studies that tested the independent and interactive...
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Fall 2016
Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer’s disease (AD) and preclinical cognitive and memory decline in older adults. We investigated whether memory resilience to genetic risk (i.e., Apolipoprotein E [APOE] ɛ4, Clusterin [CLU] CC, and a high additive...
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Stroke Prevention in Middle-Aged and Older Arab Immigrant Women: Emphasizing Strengths and Identifying Challenges
DownloadFall 2017
Arab immigrants constitute a minority group that is increasing in Canada. Minimal literature exists on Arab immigrant women’s experiences of ageing while managing health concerns. The evidence suggests that stroke risk factors are on the rise in this population with a lack of supportive resources...
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Structural changes of the amygdala subnuclei and limbic white matter tracts in healthy aging and major depressive disorder
DownloadFall 2019
The world population is dramatically aging. Several factors affect brain in healthy aging. The apolipoprotein E (APOE), brain-derived neurotrophic factor (BDNF) and catechol-O-methyl transferase (COMT) might be involved in neurodegenerative diseases, depression and cognitive decline in healthy...
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Synergistic Associations of Genetic, Demographic, Health, and Lifestyle Risk Factors on Neurocognitive Performance and Change in Aging
DownloadSpring 2016
Objective: Neurocognitive phenotypes observed in aging have been linked to select combinations of candidate genetic polymorphisms and modifiable risk factors. In this dissertation, I test multiple methods and approaches to examine three modifiable risk domains (i.e., demographic, health,...
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The Effect of Inhaled Nitric Oxide on Maximal Oxygen Consumption in High-fit and Untrained Individuals
DownloadFall 2019
Previous work suggests that endurance-trained athletes have superior pulmonary vasculature function as compared to untrained individuals, which may contribute to their greater maximal oxygen uptake (V̇O2max). Inhaled nitric oxide (iNO) improves pulmonary vascular compliance at rest in healthy...