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Skip to Search Results- 1Benesch, Matthew G. K.
- 1Brindley, David N.
- 1Curtis, Jonathan M.
- 1Dewald, Jay
- 1McMullen, Todd P. W.
- 1Patwardhan, Neeraj
- 1Autotaxin
- 1Breast Cancer
- 1Cell Migration
- 1Epidermal Growth Factor Receptor
- 1G-Protein-Coupled Receptors
- 1Lysophosphatidate
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Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice
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Dewald, Jay, Santos, Webster L., Patwardhan, Neeraj, Zhao, Yuan Y., McMullen, Todd P. W., Curtis, Jonathan M., Brindley, David N., Tang, Xiaoyun, Benesch, Matthew G. K.
Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cells that increasing LPP1 activity would decrease...