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2007

Guan, L., Guo, Y., Liu, T., Li, H., Wang, J., Zheng, W.M., Wong, G.K.

Background The main two sorts of automatic gene annotation frameworks are ab initio and alignment-based, the latter splitting into two sub-groups. The first group is used for intra-species alignments, among which are successful ones with high specificity and speed. The other group contains more...

2008

Li, R., Wang, J., Wong, G.K.S., Zheng, H., Xu, S., Clark, T., Zheng, X., Vang, S.

Background Gene conversion causes a non-reciprocal transfer of genetic information between similar sequences. Gene conversion can both homogenize genes and recruit point mutations thereby shaping the evolution of multigene families. In the rice genome, the large number of duplicated genes...

2006

Wang, W., Li, J., Liu, D., Lu, Z., Zheng, H., Wong, G., Cai, Z., Fan, C., Zhang, J., Vang, S., Long, M., Zhang, G., Wang, J., Shi, J.

Retroposition is widely found to play essential roles in origination of new mammalian and other animal genes. However, the scarcity of retrogenes in plants has led to the assumption that plant genomes rarely evolve new gene duplicates by retroposition, despite abundant retrotransposons in plants...

2007

Wang, W., Wang, H., Wong, G.K.S., Zheng, H., Clark, T., Zhang, G., Kang, L., Wang, J., Shi, J., Wang, X.

Background Insects constitute the vast majority of known species with their importance including biodiversity, agricultural, and human health concerns. It is likely that the successful adaptation of the Insecta clade depends on specific components in its proteome that give rise to specialized...

2005

Gorodkin, J., Christensen, O. F., Jørgensen, F. G., Yang, H., Bendixen, C., Brunak, S., Wernersson, R., Panitz, F., Hornshøj, H., Mailund, T., Wong, G.K.S., Dong, W., Wang, J., Li, W., Klein, A., Fredholm, M., Hu, S., Stærfeldt, H.-H., Bolund, L., Liu, B., Schierup, M. H., Yu, J.

Background Comparative whole genome analysis of Mammalia can benefit from the addition of more species. The pig is an obvious choice due to its economic and medical importance as well as its evolutionary position in the artiodactyls. Results We have generated ~3.84 million shotgun sequences...

2005

Ye, C., Wang, J., Li, S., Li, R., Wong, G.K.S., Ye, J., Yang, H., Han, Y., Yu, J.

We describe an algorithm, ReAS, to recover ancestral sequences for transposable elements (TEs) from the unassembled reads of a whole genome shotgun. The main assumptions are that these TEs must exist at high copy numbers across the genome and must not be so old that they are no longer...

2005

Xia, Q., Chen, J., Dai, M., Ye, C., Wang, J., Li, S., Li, R., Zhou, Z., Ruan, J., Hu, Y., Yu, G., Yang, H., He, X., Yu, Jun, Xiang, Z., Yuan, H., Lu, C., Feng, T.

The Silkworm Knowledgebase (SilkDB) is a web-based repository for the curation, integration and study of silkworm genetic and genomic data. With the recent accomplishment of a ~6X draft genome sequence of the domestic silkworm (Bombyx mori ), SilkDB provides an integrated representation of the...

2006

Li, R., Zheng, W., Durbin, R., Liu, T., Bolund, L., Dehal, P., Coin, L.J., Coghlan, A., Osmotherly, L., Heriche, J.K., Ruan, J., Li, H., Wang, J., Wong, G., Zhang, Z.

TreeFam is a database of phylogenetic trees of gene families found in animals. It aims to develop a curated resource that presents the accurate evolutionary history of all animal gene families, as well as reliable ortholog and paralog assignments. Curated families are being added progressively,...