Search
Skip to Search Results- 38Field, Catherine J.
- 13Gänzle, Michael G.
- 6Goruk, Susan
- 6Proctor, Spencer D.
- 6Ruth, Megan R.
- 4Azad, Meghan B.
-
Ganglioside composition of differentiated Caco-2 cells resembles human colostrum and neonatal rat intestine
Download2009
Field, Catherine J., Schnabl, Kareena L., Clandinin M. Thomas
Gangliosides are glycosphingolipids found in cell membranes and human milk with important roles in cell proliferation, differentiation, growth, adhesion, migration, signalling and apoptosis. Similar changes in ganglioside composition occur during embryonic development, lactation and cancer cell...
-
2015
Garcia-Hernandez, Rigoberto, Ruan, Lifang, Gänzle, Michael G., Zheng, Jinshui, Mercer, Ryan G., McMullen, Lynn M.
Escherichia coli AW1.7 is a heat resistant food isolate and the occurrence of pathogenic strains with comparable heat resistance may pose a risk to food safety. To identify the genetic determinants of heat resistance, 29 strains of E. coli that differed in their of heat resistance were analyzed...
-
Glutamine supplementation improves intestinal barrier function in a weaned piglet model of Escherichia coli infection
Download2011
Johnson, Ian R., Ewaschuk, Julia B., Murdoch, Gordon K., Field, Catherine J., Madsen, Karen L.
The weaning period is associated with an increased prevalence of gastrointestinal infection in many species. Glutamine (Gln) has been shown to improve intestinal barrier function and immune function in both in vivo and in vitro models. The objective of the present study was to determine the...
-
Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp rat
Download2010
Proctor, Spencer D., Lu, Jing, Shen, Jianheng, Reaney, Martin J., Wright, David C., Vine, Donna F., Jacome-Sosa, M. Miriam, Field, Catherine J., Wang, Ye, Ruth, Megan R.
Background Conjugated linoleic acid (cis-9, trans-11 CLA) and trans-11 vaccenic acid (VA) are found naturally in ruminant-derived foods. CLA has been shown to have numerous potential health related effects and has been extensively investigated. More recently, we have shown that VA has...
-
2016-01-01
Bridgman, Sarah L., Konya, Theodore, Azad, Meghan B., Sears, Malcolm R., Becker, A. B., Turvey, Stuart E., Mandhane, P. J., Subbarao, P., Scott, James A., Field, Catherine J., Kozyrskyj, Anita L.
Secretory immunoglobulin A (IgA) plays a critical role in gut mucosal immune defense. Initially provided by breastmilk, IgA production by the infant gut is gradually stimulated by developing gut microbiota. This study reports associations between infant fecal IgA concentrations 4 months after...
-
Infant gut microbiota and the hygiene hypothesis of allergic disease: Impact of household pets and siblings on microbiota composition and diversity
Download2013
Field, Catherine J., Guttman, David S., Kozyrskyj, Anita L., Maughan, Heather, Sears, Malcolm R., Konya, Theodore, Scott, James A., Becker, Allan B., Azad, Meghan B.
Background Multiple studies have demonstrated that early-life exposure to pets or siblings affords protection against allergic disease; these associations are commonly attributed to the “hygiene hypothesis”. Recently, low diversity of the infant gut microbiota has also been linked to allergic...
-
Inulin and fructo-oligosaccharides have divergent effects on colitis and commensal microbiota in HLA-B27 transgenic rats
Download2012-01-01
Koleva, Petya, Dieleman, Levinus, Sun, Xu, Gänzle, Michael G., Valcheva, Rosica
Modulation of intestinal microbiota by non-digestible carbohydrates may reduce inflammation in inflammatory bowel disease (IBD). The aim of the present study was to assess the effects of inulin and fructo-oligosaccharides (FOS) on intestinal microbiota and colitis in HLA-B27 transgenic rats, a...
-
2012
Ketabi, Ali, Baracos, Vickie E., Field, Catherine J., Lin, Xiaoxi, Xue, Hongyu, Bibova, Ilona, Gänzle, Michael G., Dieleman, Levinus A., Sawyer, Michael B.
Intestinal microbiota mediate toxicity of irinotecan (CPT-11) cancer therapies and cause systemic infection after CPT-11-induced loss of barrier function. The intestinal microbiota and their functions are thus potential targets for treatment to mitigate CPT-11 toxicity. However, microbiota...
-
Long-term effect of docosahexaenoic acid feeding on lipid composition and brain fatty acid-binding protein expression in rats
Download2015
Moncton, Elizabeth A., Brun, Miranda, Emara, Marwan, Field, Catherine J., Goruk, Susan, Godbout, Roseline, Elsherbiny, Marwa E., Richard, Caroline
Arachidonic (AA) and docosahexaenoic acid (DHA) brain accretion is essential for brain development. The impact of DHA-rich maternal diets on offspring brain fatty acid composition has previously been studied up to the weanling stage; however, there has been no follow-up at later stages. Here, we...
-
2014
Bridgman, Sarah L., Letourneau, Nicole, Field, Catherine J., Azad, Meghan B., Johnston, David W., Kozyrskyj, Anita L., Kaplan, Bonnie J.
Background Probiotic products that may modify the intestinal microbiota are becoming increasingly available and known to consumers due to their potential to prevent or treat many pediatric health conditions. As scientific knowledge of the health benefits of probiotics increases, it is important...