T Cell Generation in a Lymphopenic Environment Generates Disease when the Thoracic Thymus is Eliminated; Augmentation by IL-7/Anti-IL-7 Complexes

  • Author / Creator
    Smolarchuk, Christa
  • Cervical thymus functionally mimics the thoracic thymus in supporting T cell development and exists in a subset of mice and humans. Importantly, it remains unknown whether the cervical thymus generates an overall repertoire of T cells that are self-tolerant similar to the thoracic thymus. Mice that developed T cells in the absence of the T cell output from the thoracic thymus developed a disease characterized by lethargy, swollen eyes and cachexia. Our data supports that the cervical thymus can function in the absence of the thoracic thymus; however, the T cell repertoire is not fully self-tolerant. Evidence suggests that disease occurs as a result of lymphopenia-driven autoimmunity similar to disease seen after transfer of thymocytes into lymphopenic hosts. Therefore, we used this model to demonstrate that IL-7, an important homeostatic cytokine, can augment disease although the mechanism remains to be elucidated.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • Department of Medical Microbiology and Immunology
  • Specialization
    • Immunology
  • Supervisor / co-supervisor and their department(s)
    • Anderson, Colin (Surgery and Medical Microbiology and Immunology)
  • Examining committee members and their departments
    • Agrawal, Babita (Surgery)
    • Elliott, John (Medicine)
    • Baldwin, Troy (Medical Microbiology and Immunology)