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Characterizing tolerance in CD8 T cells in the absence of Bim-mediated clonal deletion to tissue restricted antigensDownload
T cells are part of the adaptive immune system that eliminate pathogen-infected cells, but do not harm healthy cells. Precursor T cells, termed thymocytes, develop in the thymus where they randomly generate and express unique antigen specific T cell receptors (TCR) during the CD4+CD8+ double...
Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounterDownload
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
T cells are a vital part of the adaptive immune system that function to eliminate foreign threats while remaining tolerant to healthy-self. During T cell development in the thymus, T cells are generated with various T cell receptor (TCR) specificities, such that they can respond to a near endless...
MUC1, a protein of epithelial and carcinoma cells, has recently been shown on activated T cells where it inhibits CD3-stimulated proliferation. Two immunoregulatory domains similar to ITAM and ITIMs are present on its cytoplasmic tail, suggesting that MUC1 can act as both a costimulatory and...
Background: NK cells are a key cellular component of antibody-mediated rejection (ABMR), but their role in ABMR has not been identified. We postulated that NK cells are stimulated through their CD16a antibody receptors by donor-specific anti-HLA antibodies in ABMR. There is currently no direct...