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- 1Adam, Ibrahim S. Y.
- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Azaizeh, Bara'ah
- 1Bacik, John-Paul
- 8Evans, David (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Ingham, Robert (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 4Foley, Edan (Medical Microbiology and Immunology)
- 3Baldwin, Troy (Medical Microbiology and Immunology)
Characterization of Galectin-9+ and TIGIT+ Natural Killer Cells in Human Immunodeficiency Virus-1 Infected IndividualsDownload
NK cells play an integral role in mediating immune responses to viral infections; however, their function is compromised during chronic diseases such as HIV-1, partly due to an increase in expression of inhibitory receptors. Thus, one of the reasons for the reduced immune responses elicited by NK...
Investigating barriers to vaccinia virus recombination using combinations of light and electron microscopyDownload
While DNA viruses typically replicate in the nucleus of the host cell, poxvirus replication occurs exclusively within cytoplasmic structures known as viral factories. Viral factories are the sites of various processes of the vaccinia virus (VACV) life cycle including replication, morphogenesis...
A large deletion virus reveals the presence of previously uncharacterized vaccinia virus inhibitors of NF-kB signalingDownload
The classical Nuclear Factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immune responses. Poxviruses, including vaccinia virus, encode multiple immune evasion proteins, including a growing number of NF-κB inhibitors. To determine if additional vaccinia...
A tale of two hypotheses: Effect of the herpes simplex-1 virus virion host shutoff (vhs) protein on bicistronic reportersDownload
The herpes simplex virus virion host shutoff (vhs) protein acts as an mRNA specific endoribonuclease. Our lab has previously determined that vhs stimulates expression of the 3’ CAT cistron of a bicistronic reporter plasmid while under the influence of the BiP IRES; however, the mechanism by which...
Introduction: ABO-incompatible organ transplants (ABOi-Tx) recipients are at high-risk of rapid rejection mediated by ABO antibodies (ABO Abs). To manage and expand ABOi-Tx, it is necessary to understand the mechanism(s) by which natural and induced ABO Abs develop. Prior studies have used...
Positive strand RNA ((+)ssRNA) viruses are some of the most important pathogens that impact the public health, economy, and quality of life. The interferon (IFN) response plays a critical role in innate immune response targeting (+)ssRNA viruses, which in turn have evolved various strategies to...