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- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Banadyga, Logan Elliott
- 1Beatty, Jessica
- 1Benjamin Kostiuk
- 7Evans, David (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 4Foley, Edan (Medical Microbiology and Immunology)
- 4Ingham, Robert (Medical Microbiology and Immunology)
- 3Baldwin, Troy (Medical Microbiology and Immunology)
Characterization of Galectin-9+ and TIGIT+ Natural Killer Cells in Human Immunodeficiency Virus-1 Infected IndividualsDownload
NK cells play an integral role in mediating immune responses to viral infections; however, their function is compromised during chronic diseases such as HIV-1, partly due to an increase in expression of inhibitory receptors. Thus, one of the reasons for the reduced immune responses elicited by NK...
Investigating barriers to vaccinia virus recombination using combinations of light and electron microscopyDownload
While DNA viruses typically replicate in the nucleus of the host cell, poxvirus replication occurs exclusively within cytoplasmic structures known as viral factories. Viral factories are the sites of various processes of the vaccinia virus (VACV) life cycle including replication, morphogenesis...
A large deletion virus reveals the presence of previously uncharacterized vaccinia virus inhibitors of NF-kB signalingDownload
The classical Nuclear Factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immune responses. Poxviruses, including vaccinia virus, encode multiple immune evasion proteins, including a growing number of NF-κB inhibitors. To determine if additional vaccinia...
A tale of two hypotheses: Effect of the herpes simplex-1 virus virion host shutoff (vhs) protein on bicistronic reportersDownload
The herpes simplex virus virion host shutoff (vhs) protein acts as an mRNA specific endoribonuclease. Our lab has previously determined that vhs stimulates expression of the 3’ CAT cistron of a bicistronic reporter plasmid while under the influence of the BiP IRES; however, the mechanism by which...
The influenza virus can cause severe respiratory illness in humans and animals. There are four types of influenza viruses (A, B, C, and D); however, only type A and B cause severe diseases in humans. Influenza virus belongs to the family Orthomyxoviridae, which includes segmented negative-sense...
CNS Inflammasome Activation and Pyroptosis in Multiple Sclerosis and Experimental Autoimmune EncephalomyelitisDownload
Multiple sclerosis (MS) is a progressive and incurable demyelinating disease of the central nervous system (CNS). The neuropathogenesis of MS and its prototypic animal model, experimental autoimmune encephalomyelitis (EAE), is defined by persistent neuroinflammation, involving the activation of...
The fine balance struck between life and death is key for the health of all multicellular organisms and therefore the pathways that govern life and death decisions are evolutionarily highly conserved. For example, the human TNF and the Drosophila IMD pathways coordinate signaling elements such...