Environmental Exposures, Gut Microbiota, and Urinary Metabolomic Fingerprint of Crohn’s Disease Patients Who Have Undergone Ileo-colonic Resection

• Author / Creator

  Tso, Robert

• Inflammatory bowel disease (IBD) is an idiopathic disease that causes intestinal inflammation and lesions. Canada has one of the highest rates of IBD in the world. One of the major types of IBD is Crohn’s Disease (CD) and a large portion of CD patients will undergo surgical resection in the course of their disease. However, up to 90% of these patients will have endoscopic recurrence by 5 years post-surgery. The cause of the recurrence is unknown, but is thought to follow the same course as the initial onset of Crohn’s lesions. In this study CD patients in endoscopic remission and relapse that have undergone ileocolonic resection were compared. Results show there were specific changes in gut microbial composition, variations in urinary metabolites and unique environmental exposures, both current and childhood, between the remission and relapse patients.

• Subjects / Keywords

  • Surgery
  • Metabolomics
  • Postoperative recurrence
  • Crohn's disease
  • Ileocolonic resection
  • Microbiota
  • Environmental exposures

• Graduation date

  Spring 2014

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R3R20S364

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.