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- 2Coulombe, Marilyne G.
- 2Logus, J. Wayne (John Wayne), 1951-
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Agrawal, Amogh
- 1Ahmed, Iqbal Hussein, 1953-
- 7Primary Biliary Cholangitis
- 6Inflammatory bowel disease
- 5Inflammatory Bowel Disease
- 4B cells
- 4Endothelial cells
Background: Cancer-associated venous thromboembolism (VTE) is associated with significant morbidity and mortality. Cancer patients are at higher risk of VTE recurrence despite anticoagulation and bleeding complications while on anticoagulation. There are some risk factors of bleeding specific...
Utility of Screening-Bead Assay in Testing for Formation of Donor-Specific Anti-HLA Antibodies and Antibody-Mediated Rejection in Renal Allografts Post-Transplant.Download
Background: Present-day immunosuppressive therapy in renal allograft recipients targets cell-mediated immunity and has significantly improved outcomes over the years. However, allograft failure rates still approach 50% towards 10 years post-transplantation. Antibody-mediated rejection (ABMR) is...
A Discrete Choice Experiment Pilot Study: Understanding Patient Preferences for In-centre HemodialysisDownload
Background: End-stage kidney disease (ESKD) is the failure of functioning kidneys such that they no longer have the capacity to sustain life without intervention. While the incidence of ESKD has remained generally stable across all ages of Canadians since 2000, the prevalence of ESKD has been...
Aims: This study aims to 1) provide a platform to discuss and document one First Nations community’s experiences and impacts of tuberculosis (TB); and 2) to understand the social context occurring within the community which may promote continual disease transmission. Methods: This Community-Based...
In Pulmonary Arterial Hypertension (PAH), pro-constrictive, pro-proliferative and anti-apoptotic diatheses converge to produce contraction and excessive proliferation of pulmonary artery smooth muscle cells (PASMC), a hallmark of PAH-vascular remodeling. The increased afterload causes right...
A Novel Association Between Primary Biliary Cholangitis and Idiopathic Pulmonary Arterial HypertensionDownload
Background and Hypothesis Idiopathic Pulmonary Arterial Hypertension (IPAH) and Primary Biliary Cholangitis (PBC) are both rare diseases that are progressive and may be fatal when left untreated. Furthermore, mitochondrial dynamics are fundamental to the pathogenesis of both conditions. An...
A Retrospective Analysis of the Safety and Efficacy of a 6-Week Pulmonary Rehabilitation Program in Patients with Severe Pulmonary Arterial HypertensionDownload
Pulmonary Arterial Hypertension (PAH) is progressive disease characterized by reduced exercise capacity and decreased quality of life. Despite the availability of disease targeted therapies outcomes remain sub-optimal. Pulmonary Rehabilitation has proven to improve outcomes in other chronic...
A Retrospective Study on Potential Organ Donation and Transplantation Opportunities in Alberta Emergency Rooms and Intensive Care UnitsDownload
Background: In patients with end stage organ failure, organ transplant is often the only life saving treatment. Unfortunately, worldwide, the number of organs needed for transplant far outnumber the number of organs available. This scarcity of organs has led to interest in methods of increasing...
A Reversible Metabolic Stress-Sensitive Regulation of Collapsin Response Mediator Protein 2A Orchestrates Cytoskeletal Remodeling and EMT, Increasing Metastatic Potential in CancerDownload
Cancer represents the second leading cause of death globally only after heart disease and is responsible for about 10 million deaths per year with a significant economic impact (WHO facts). Moreover, its prevalence is projected to increase over the following decades. Among all cancers, breast,...