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- 2Coulombe, Marilyne G.
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Agrawal, Amogh
- 1Ajamian, Farnam
- 1Al-Karaghouli, Mustafa Thaier Salman
- 6Inflammatory bowel disease
- 4B cells
- 4Endothelial cells
- 4Myocardial infarction
- 4Primary Biliary Cholangitis
Background: Cancer-associated venous thromboembolism (VTE) is associated with significant morbidity and mortality. Cancer patients are at higher risk of VTE recurrence despite anticoagulation and bleeding complications while on anticoagulation. There are some risk factors of bleeding...
Utility of Screening-Bead Assay in Testing for Formation of Donor-Specific Anti-HLA Antibodies and Antibody-Mediated Rejection in Renal Allografts Post-Transplant.Download
Background: Present-day immunosuppressive therapy in renal allograft recipients targets cell-mediated immunity and has significantly improved outcomes over the years. However, allograft failure rates still approach 50% towards 10 years post-transplantation. Antibody-mediated rejection (ABMR) is...
Aims: This study aims to 1) provide a platform to discuss and document one First Nations community’s experiences and impacts of tuberculosis (TB); and 2) to understand the social context occurring within the community which may promote continual disease transmission. Methods: This...
In Pulmonary Arterial Hypertension (PAH), pro-constrictive, pro-proliferative and anti-apoptotic diatheses converge to produce contraction and excessive proliferation of pulmonary artery smooth muscle cells (PASMC), a hallmark of PAH-vascular remodeling. The increased afterload causes right...
A Novel Association Between Primary Biliary Cholangitis and Idiopathic Pulmonary Arterial HypertensionDownload
Background and Hypothesis Idiopathic Pulmonary Arterial Hypertension (IPAH) and Primary Biliary Cholangitis (PBC) are both rare diseases that are progressive and may be fatal when left untreated. Furthermore, mitochondrial dynamics are fundamental to the pathogenesis of both conditions. An...
A Retrospective Analysis of the Safety and Efficacy of a 6-Week Pulmonary Rehabilitation Program in Patients with Severe Pulmonary Arterial HypertensionDownload
Pulmonary Arterial Hypertension (PAH) is progressive disease characterized by reduced exercise capacity and decreased quality of life. Despite the availability of disease targeted therapies outcomes remain sub-optimal. Pulmonary Rehabilitation has proven to improve outcomes in other chronic...
A Retrospective Study on Potential Organ Donation and Transplantation Opportunities in Alberta Emergency Rooms and Intensive Care UnitsDownload
Background: In patients with end stage organ failure, organ transplant is often the only life saving treatment. Unfortunately, worldwide, the number of organs needed for transplant far outnumber the number of organs available. This scarcity of organs has led to interest in methods of increasing...
A Study of the Protein Phosphatase 1 (PP1) Regulatory Subunit, TIMAP, in Human Glomerular Endothelial CellsDownload
TIMAP is a prenylated endothelial-predominant regulatory subunit for the serine/threonine (Ser,S/Thr,T) protein phosphatase 1 catalytic subunit (PP1c). TIMAP was first discovered in glomerular endothelial cells. It is expressed in the developing blood vessels of kidney, and its transcription in...
A convergence of cultures and strategies to improve Electronic Health Record implementation within a Tanzanian clinical environmentDownload
This research explored the question: “How can we improve the implementation of an Electronic Health Record (EHR) within a Tanzanian clinical environment?” The objectives included working with local stakeholders to identify opportunities to improve, and exploring barriers and facilitators to...