Download the full-sized PDF of An atlas of DNA methylomes in porcine adipose and muscle tissuesDownload the full-sized PDF



Permanent link (DOI):


Export to: EndNote  |  Zotero  |  Mendeley


This file is in the following communities:

Roy Berg Kinsella Research Ranch


This file is in the following collections:

Journal Articles (Kinsella Ranch)

An atlas of DNA methylomes in porcine adipose and muscle tissues Open Access


Author or creator
Li, M.
Wu, H.
Luo, Z.
Xia, Y.
Guan, J.
Wang, T.
Gu, Y.
Chen, L.
Zhang, K.
Ma, J.
Liu, Y.
Zhong, Z.
Nie, J.
Zhou, S.
Mu, Z.
Wang, X.
Qu, J.
Jing, L.
Wang, H.
Huang, S.
Yi, N.
Wang, Z.
Xi, D.
Wang, J.
Yin, G.
Wang, L.
Li, N.
Jiang, Z.
Lang, Q.
Xiao, H.
Jiang, A.
Zhu, L.
Jiang, Y.
Tang, G.
Mai, M.
Shuai, S.
Li, K.
Zhang, X.
Li, Y.
Chen, H.
Gao, X.
Plastow, G. S.
Beck, S.
Yang, H.
Wang, Y.
Li, X.
Additional contributors
biological sciences
molecular biology
Type of item
Journal Article (Published)
It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct skeletal muscle tissues from three pig breeds living within comparable environments but displaying distinct fat level. We generate 1,381 Gb of sequence data from 180 methylated DNA immunoprecipitation libraries, and provide a genome-wide DNA methylation map as well as a gene expression map for adipose and muscle studies. The analysis shows global similarity and difference among breeds, sexes and anatomic locations, and identifies the differentially methylated regions. The differentially methylated regions in promoters are highly associated with obesity development via expression repression of both known obesity-related genes and novel genes. This comprehensive map provides a solid basis for exploring epigenetic mechanisms of adipose deposition and muscle growth.
Date created
License information
Attribution-NonCommercial 4.0 International

Citation for previous publication
Li, M., Wu, H., Luo, Z., Xia, Y., Guan, J., Wang, T., Gu, Y., Chen, L., Zhang, K., Ma, J., Liu, Y., Zhong, Z., Nie, J., Zhou, S., Mu, Z., Wang, X., Qu, J., Jing, L., Wang, H., Huang, S., Yi, N., Wang, Z., Xi, D., Wang, J., Yin, G., Wang, L., Li, N., Jiang, Z., Lang, Q., Xiao, H., Jiang, A., Zhu, L., Jiang, Y., Tang, G., Mai, M., Shuai, S., Li, N., Li, K., Wang, J., Zhang, X, Li, Y., Chen, H., Gao, X., Plastow, G.S., Beck, S., Yang, H., Wang, J., Wang, Y., Li, X., Li,R. (2012). An atlas of DNA methylomes in porcine adipose and muscle tissues. Nature Communications Volume, 3(850),

Link to related item

File Details

Date Uploaded
Date Modified
Audit Status
Audits have not yet been run on this file.
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 8720725
Last modified: 2016:06:24 18:54:41-06:00
Filename: ncomms1854
Original checksum: 56cd6299732693f5c7018b7522dcaa97
Copyright note: ?? 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Well formed: true
Valid: true
File title: An atlas of DNA methylomes in porcine adipose and muscle tissues
File author: Mingzhou Li
Page count: 11
Activity of users you follow
User Activity Date