Download the full-sized PDF of Nutrient availability, the microbiome and intestinal transport during pregnancyDownload the full-sized PDF



Permanent link (DOI):


Export to: EndNote  |  Zotero  |  Mendeley


This file is in the following communities:

Agricultural, Life, and Environmental Sciences, Faculty of


This file is in the following collections:

Journal Articles (Agricultural, Life, & Environmental Sciences)

Nutrient availability, the microbiome and intestinal transport during pregnancy Open Access


Author or creator
Astbury, S.
Mostyn, A.
Symonds, M.E.
Bell, R.C.
Additional contributors
gastrointestinal adaptation
maternal health
54 nutrient transport
Type of item
Research Material
Adequate adaptation of the gastrointestinal (GI) tract is important during pregnancy to ensure that the increased metabolic demands by the developing fetus are met. These include changes in surface area mediated by villus hypertrophy and enhanced functional capacity of individual nutrient receptors including those transporting glucose, fructose, leucine, and calcium. These processes are regulated either by the enhanced nutrient demand or are facilitated by changes in the secretion of pregnancy hormones. Our review also covers recent research into the microbiome, and how pregnancy could lead to microbial adaptations, which are beneficial to the mother, yet are also similar to those seen in the metabolic syndrome. The potential role of diet in modulating the microbiome during pregnancy, as well as the potential for the intestinal microbiota to induce pregnancy complications are examined. Gaps in the current literature are highlighted including those where only historical evidence is available, and we suggest areas that should be a priority for further research. In summary, although a significant degree of adaptation has been described, there are both well-established processes, and more recent discoveries such as changes within the maternal microbiome that pose new questions as to how the GI tract effectively adapts to pregnancy, especially in conjunction with maternal obesity.
Date created
License information
© 2015 NRC Press/Astbury et al. This version of this article is open access and can be downloaded and shared. The original authors and source must be cited.
Citation for previous publication
Astbury, S., Mostyn, A., Symonds, M.E., Bell, R.C. (2015). Nutrient availability, the microbiome and intestinal transport during pregnancy. Applied Physiology, Nutrition, and Metabolism,

Link to related item

File Details

Date Uploaded
Date Modified
Audit Status
Audits have not yet been run on this file.
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 370274
Last modified: 2016:06:24 18:50:56-06:00
Filename: Astbury 2015 Intestinal adaptations to pregnancy apnm-2015-0117.pdf
Original checksum: 0688ea44f663768177ec8649da54222f
Well formed: false
Valid: false
Status message: Invalid page dictionary object offset=368900
File title: Nutrient availability, the microbiome and intestinal transport during pregnancy
File author: Dr. Stuart Astbury, Dr. Alison Mostyn, Prof. Michael E Symonds, Dr. Rhonda C Bell
Activity of users you follow
User Activity Date