General Internal Medicine
Items in this Collection
- 2Cardiac Troponin
- 2Chemical cleavage
- 2Fusion protein expression
- 2Intrinsically disordered regions
- 2Myocardial Infarction
- 2Randomized Controlled Trials as Topic
Incidence of Catheter-Related VTE in Acute Leukemia Patients Requiring Peripherally-Inserted Central CatheterDownload
Resident research day for Core Internal Medicine. Background- Central venous catheters (CVCs) are a leading cause of upper extremity deep vein thrombosis (UE DVT). Long term CVCs are required for chemotherapy in acute leukemia (AL), who can be thrombocytopenic which makes anticoagulation for CVC...
Introduction: As one of the geriatric giants, frailty is a state of decreased physiological reserve and increased vulnerability that results from the collective decline in multiple systems. It manifests as a heterogeneous, multidimensional syndrome. However, several studies have shown that older...
Background: The serum troponin assay is the biochemical gold standard for detecting myocardial infarction (MI). A major diagnostic issue is that some believe troponin levels can rise with reversible injury, in the absence of radiologically detectable infarct. Hypothesis: Because cell death...
Quality of Life (QOL) in Diabetics with Multi-Vessel Coronary Artery Disease: Real-World Experience Comparing Percutaneous Coronary Intervention (PCI) and Coronary Artery Bypass Grafting (CABG)Download
Introduction Studies demonstrate mortality benefit supporting CABG over PCI in diabetics with multi-vessel CAD. However, CABG is associated with longer recovery and higher stroke rates. Thus, while CABG prolongs life it’s impact on QOL warrants study. This study utilizes comprehensive...
Recombinant expression of the cardiac troponin I fragment, cTnI[135-209], that controls cardiac contractionDownload
Intrinsically disordered regions (IDRs) are protein segments that lack a fixed three-dimensional structure under physiologic conditions, they are susceptible to post-translational modifications such as proteolysis. However, they are highly important in cellular signal transduction and the...
Troponin degradation products: more specific marker for myocardial infarction
Introduction Myocardial infarction (MI) is the death of cardiac muscle in the setting of severe ischemia (lack of oxygen and nutrient supply). Assay of serum troponin I (TnI) is the biochemical gold standard for detecting MI. With the development of high sensitivity assays, TnI is being detected...