Communities and Collections

Incidence of Catheter-Related VTE in Acute Leukemia Patients Requiring Peripherally-Inserted Central Catheter

  • Author(s) / Creator(s)
  • Resident research day for Core Internal Medicine. Background- Central venous catheters (CVCs) are a leading cause of upper extremity deep vein thrombosis (UE DVT). Long term CVCs are required for chemotherapy in acute leukemia (AL), who can be thrombocytopenic which makes anticoagulation for CVC related thrombosis a challenge. Incidence of UE DVT has been reported to be increased in those with peripherally inserted (PICC) vs centrally inserted lines. Aims- To identify leukemia inpatients with a PICC line and report the incidence of VTE. Methods- AL inpatients admitted to Hematology at the University of Alberta Hospital between 2003-2013 and who required PICC insertion were identified, and their charts reviewed retrospectively. Baseline patient characteristics were recorded. All VTE were objectively confirmed on imaging studies. Incidence of catheter associated thrombosis was calculated. Results- 420 patients with AL were identified. 83 patients were excluded for not undergoing a PICC insertion. The remaining 337 patients had at least one PICC line insertion. Overall, there were 634 PICC line insertions, with the 5FR dual lumen being the most commonly used PICC line (80%). Out of the 634 insertions, there were 65 (10%) new upper extremity DVTs, 54 (83%) of which developed acutely (<1month). Conclusions- The incidence rate of DVT in our AL patients is higher than predicted for a general cancer patient population.

  • Date created
  • Subjects / Keywords
  • Type of Item
    Conference/Workshop Poster
  • DOI
  • License
    CC0 1.0 Universal