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The role of the Prader-Willi syndrome obesity protein, MAGEL2 in the proper functioning of circadian rhythm
DownloadFall 2010
MAGEL2 is one of the five genes inactivated in Prader-Willi Syndrome (PWS), a genetic disorder, manifesting with symptoms of developmental delay and morbid obesity. Magel2 is highly expressed in the suprachiasmatic nucleus, which is the location of the central clock or circadian pacemaker. Magel2...
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Spring 2010
Infection of most cell types with herpes simplex virus (HSV) mutants lacking the activation functions of VP16 and/or ICP0 results in repression of viral gene expression. However, the human osteosarcoma cell line U2OS supports the replication of VP16 and ICP0 mutants to nearly wild type levels. ...
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The roles of Pbx and Meis TALE-class homeodomain transcription factors in vertebrate neural patterning
DownloadFall 2010
One of the major goals of developmental biology is to understand how specialized groups of cells arise from an initially unspecified cell population. The vertebrate hindbrain is transiently segmented along its anterior-posterior axis into lineage-restricted compartments called rhombomeres, making...
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The roles of vestigial and scalloped in the embryonic muscle development of Drosophila melanogaster
DownloadFall 2010
Vertebrate development requires the activity of multiple members of the myocyte enhancer factor 2 (mef2) gene family for muscle cell specification and subsequent differentiation. Additionally, it is thought that several muscle-specific functions of MEF2 family proteins require binding additional...
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The Singular Spectrum Analysis method and its application to seismic data denoising and reconstruction
DownloadFall 2010
Attenuating random and coherent noise is an important part of seismic data processing. Successful removal results in an enhanced image of the subsurface geology, which facilitate economical decisions in hydrocarbon exploration. This motivates the search for new and more efficient techniques for...
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The SNARC Effect as a Tool to Examine Crosstalk during Numerical Processing in a PRP paradigm
DownloadSpring 2010
The phenomenon where small numbers produce faster left than right responses and large numbers produce faster right than left responses (The SNARC effect) has been used as evidence for obligatory activations of magnitude. In two experiments, I used the SNARC effect to examine crosstalk using a...
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Spring 2010
Research on all tested vertebrates indicates that geometric information plays a special role when organisms reorient in their environment. Some researchers have argued that geometric information is processed automatically, while landmark information is processed more slowly. These conclusions of...
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Spring 2010
Neural prostheses (NPs) are electronic stimulators that activate nerves to restore sensory or motor functions. Surface NPs are non-invasive and inexpensive, but are often poorly selective, activating non-targeted muscles and cutaneous sensory nerves that can cause pain or discomfort. Implanted...
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2010
Demand for organically produced food products is increasing rapidly in North America, driven by a perception that organic agriculture results in fewer negative environmental impacts and yields greater benefits for human health than conventional systems. Despite the increasing interest in organic...