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Skip to Search Results- 4Oncology, Department of
- 4Oncology, Department of/Medical Oncology
- 1Rehabilitation Medicine, Faculty of
- 1Rehabilitation Medicine, Faculty of/Physical Therapy
- 1Surgery, Department of
- 1Surgery, Department of/General Surgery
- 2Tuszynski, Jack A.
- 1 Dumonte, Charles
- 1 Preto, Jordane
- 1 Spasevska, Ivana
- 1 Tuszynski, Jack A
- 1 Winter, Philip
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2010-01-01
McNeely, Margaret L., Campbell, Kristin, Ospina, Maria, Rowe, Brian H., Dabbs, Kelly, Klassen, Terry P., Mackey, John, Courneya, Kerry S.
Background Upper-limb dysfunction is a commonly reported side effect of treatment for breast cancer and may include decreased shoulder range of motion (the range through which a joint can be moved) (ROM) and strength, pain and lymphedema. Objectives To review randomized controlled trials (RCTs)...
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Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
Download2017-08-02
Ayoub, Ahmed T , Dumonte, Charles, Wong, Gane K-S, Preto, Jordane, Tuszynski, Jack A, Spasevska, Ivana, Winter, Philip
Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and...
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Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
Download2017-08-02
Spasevska, Ivana , Wong, Gane K.-S. , Preto, Jordane , Winter, Philip , Dumontet , Charles , Ayoub, Ahmed T. , Tuszynski, Jack A.
Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and...
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2016-12-09
Winter, Philip, Wang, Xumin, Mackey, John R. , Lee, John C. , Wong, Gane Ka-Shu, Ghosh, Sunita, Patterson, Jordan, Zhang, Hangxiao, Wang, Weiwei, Tuszynski, Jack A. , Katsetos, Christos D., Graham, Kathryn, Luduena, Richard F.
Tubulin is the target for very widely used anti-tumor drugs, including Vinca alkaloids, taxanes, and epothilones, which are an important component of chemotherapy in breast cancer and other malignancies. Paclitaxel and other tubulin-targeting drugs bind to the β subunit of tubulin, which is a...