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Zebrafish embryos exposed to alcohol undergo abnormal development of motor neurons and muscle fibers
DownloadFall 2009
Children with Fetal Alcohol Spectrum Disorder have significantly delayed motor skills, and deficiencies in reflex development. The reasons underlying these motor deficits are not fully understood. The purpose of this thesis was to investigate the effect of embryonic exposure to ethanol (EtOH) on...
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Zebrafish Targeted Mutagenesis to Unveil Normal Physiological Functions of, and Interactions between, Prion Protein (PrP) and Amyloid Precursor Protein (APP): Relevance to Alzheimer’s disease
DownloadSpring 2017
Much of the work on Prion Protein (PrPC) and Amyloid Precursor Protein (APP) biology has focused on the contributions of their misfolded forms or aggregated metabolites to prion diseases and Alzheimer’s disease, respectively. As subversion/partial loss of some normal functions are also likely...
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Zero-Sequence-Voltage-Based Detection and Localization Schemes for False Data Injection Attacks in Multiphase Power Distribution Systems
DownloadFall 2022
Modern power systems are vulnerable to false data injection attacks (FDIAs) due to the widespread applications of two-way communication networks for system operation and control. Diagnosing such malicious attacks are of great significance for the resilient operations of power systems. Firstly, to...
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Zic transcription factors regulate retinoic acid metabolism during zebrafish neural development
DownloadSpring 2012
Retinoic acid (RA) has a crucial role in embryonic nervous system development - controlling anterior-posterior patterning, neural differentiation, and cell proliferation. During zebrafish embryogenesis, levels of RA are tightly regulated by the combinatorial action of synthesis and degradation...
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Fall 2019
Acting as a co-factor for hundreds of enzymes, zinc (Zn) is an essential trace metal required for organismal success across all phyla. When aquatic organisms such as fish are Zn deficient, growth, metabolism, and health are all negatively impacted. However, Zn in excess may also impair overall...
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Zinc in Precambrian iron formations: The record, partitioning, diagenetic effects and implications for eukaryotic metallome evolution
DownloadFall 2013
Zinc is amongst the most important trace elements for eukaryotes. Previous work has suggested it to have been at biolimiting concentrations for much of the Precambrian, thereby limiting eukaryotic evolution. Yet, the iron formation (IF) record, a critical proxy for paleomarine conditions, has...