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Spring 2015

Motamedi, Pooyan

III-nitride semiconductors have a combination of structural characteristics and engineering properties that give them a unique place among semiconductors. The fact that they have the same crystal structure makes it possible to deposit alloys with fine-tuned band gaps from infrared to ultraviolet

the three-dimensional growth occurs afterwards. In-situ ellipsometry was employed to investigate the evolution of optical properties of the films during growth, and the results are in good agreement with structural observations.

Spring 2014

Melnik, Alexander

combined properties of metallic structural fuse and friction damper can achieve superior performance while being a cost-effective solution. An experimental program was conducted to evaluate hysteretic response of six configurations of prototype brace member. Physical tests demonstrate that proposed energy

dissipater can sustain axial deformation of up to 140.0 mm under incrementally increasing cyclic load. Parametric study was performed using FEA to evaluate and postpone out-of-plane buckling within metallic structural fuse that was observed during the experiment. Experimental program results demonstrate that

Fall 2021

Ilozumba, Eziolu SI

Buried pipeline systems often transverse regions with a wide variety of soil types, geological conditions, or regions of varying seismicity, exposing these buried infrastructures to severe geohazards that pose a significant amount of risk to their structural and mechanical integrity. The

performance of these buried pipelines is a crucial engineering consideration in the oil and gas industry because its failure can cause severe risks to public safety and properties. Although pertinent efforts have been made to curb these pipeline incidents caused by abrupt ground movements, the existing

experimental tests. The results of laboratory testing and numerical simulations confirm the efficiency of the proposed remediation technique in improving the structural integrity of buried pipelines.

Fall 2023

ZHU, MENGNAN

The electrochemical reduction of carbon dioxides (CO2RR) is a promising solution for mitigating CO2 emissions while simultaneously generating value-added chemicals. From the perspective of materials engineering, understanding the structure-function relationships is crucial in guiding the rational

design of electrocatalysts and advancing CO2RR technologies. Considering its significance attached, this thesis endeavors to investigate the i) BaBiO3 (BBO) perovskite, ii) Bi- and iii) Co-based electrocatalysts with atomically distributed active sites, with particular focus on how the key structural

features including potential-driven reconstructions, coordination environment, and local geometry affect the catalytic performances of CO2RR. The first part of this thesis delves into the investigation of the voltage-driven structural reconstructions in the perovskite BBO, resulting in the generation of

Fall 2015

Diner, Colin E

Asphaltenes constitute the most difficult sub-class of bitumen with regards to upgradability. This is due to their complex and variable structure, higher average molecular weight, and inclusion of polar functionalities. These structural traits instigate intermolecular attractions that lead to

molecule has been characterized structurally. A reverse-engineering approach towards accurate modeling of theoretical class members is expected to have great potential in unraveling the mysteries that remain. In this dissertation is described the first concise and scalable synthesis of a range of well

-defined asphaltene model compounds obtained in high purity. This new class of synthetic compounds falls within the observed structural guidelines determined for natural samples, both in terms of molecular weight and heteroatom content. These model compounds represent the “archipelago-type” architecture

Spring 2023

Zhang, Shuce

engineering optogenetic tools, antibodies, membrane proteins, and other targets of interest for mammalian systems. In ‎Chapter 2, I will describe my original work of developing an optogenetic tool for light-induced ER Ca2+ release. This tool is a binary system consisting of an Orai channel rerouted to ER

irreversible attP × attB recombination, with the gene of interest (GOI) placed downstream of a mammalian promoter in the landing pad. This GOI thus becomes the only copy that is expressed in this cell. I report the creation and identification of a clone of stable cell harbouring a single copy of landing pad

pattern of conformational change of 201-207 loop were identified through the ASMD simulation. The structural and mechanistic insights facilitated the directed evolution of PhoCl2 variants with improved dissociation efficiency and kinetics.

Spring 2013

Negara, Natalia

, maintenance and testing of this type of web applications. In this work we address two important challenges in the field of web application maintenance. The first challenge is that of modelling web application behaviour. To solve this task we develop an automatic method for reverse engineering the features of

dynamic web applications by applying a hierarchical clustering algorithm based on a novel composite-tree-edits-aware distance metric between DOM tree instances of a web application. The proposed distance metric recognizes simple and composite structural changes in a DOM tree. We have evaluated our method

Fall 2014

Swayampakula, Mridula

the prion protein. This dissertation examines the structural characterization of the two anti-PrP monoclonal antibodies - POM2 and POM6 in complex with their respective epitopes in the mouse prion protein. We successfully report the crystal structure of a tandem OR peptide of PrPC bound to the POM2

the unbound octapeptide repeats resulting in their extended conformation. As many OR ligands have been found to show therapeutic potential by delaying the disease onset, the structural study presented in this dissertation makes important contributions to designing smaller and tighter binding OR

ligands to improve the efficacy of their binding in vivo. We also successfully report the crystal structure of the mouse PrP125-225 bound to the POM6 Fab that was solved at a resolution of 1.83 Å. The POM6 Fab was found to have epitopes on all the three α-helices of the prion protein. An analysis of the

Fall 2018

Santos, Eddie

There is a wealth of software development artifacts such as source code, issue reports, and revision histories, contained within publicly-accessible and privately-accessible repositories. Mining this data presents myriad opportunities that may benefit future software development efforts; however it

the build; clustering crash reports in a scalable and time-efficient manner; and detecting and correcting syntax errors in code written by novices. This thesis empirically demonstrate the effectiveness of these tools on real world software repositories. I conclude by suggesting ways of further

Fall 2015

Kostic, Branislav Z

Structural Health Monitoring (SHM) has become a very important area in civil engineering for evaluating the performance of critical civil infrastructure systems such as bridges. One of the most important issues with continuous SHM is the environmental effects (such as temperature, humidity, wind