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Cognitive Resilience to Frailty and Mobility Adversities in Aging: Data-Driven Approach to Classification and Prediction by Risk Factors for Alzheimer’s Disease
DownloadSpring 2021
Objective: The overall aim of the current dissertation was to examine how and why some older adults maintain their cognitive performance for long periods of time, despite the presence of physical adversity factors known to be associated with the deterioration of cognitive function. We examined...
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Integrating Characteristics of Executive Functions in Non-Demented Aging: Structure, Trajectories, Classification, and Biomarker Predictors
DownloadSpring 2019
In aging, executive function (EF) performance (level) and change (trajectory) are linked to multiple interacting risk factors. Structurally, EFs have previously been represented as either a unitary (e.g., unidimensional) or diverse (e.g., multidimensional) set of abilities that change across the...
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Longitudinal Associations of Genetic Polymorphisms and Personality Traits: Independent and Interactive Effects on Neurocognitive Performance in Older Adults
DownloadFall 2013
Research has linked multifaceted neurocognitive phenotypes to genetic polymorphisms and environmental factors. This study examines associations of personality traits and single nucleotide polymorphisms (SNPs) on cognition. Structural equation modeling was used to examine (a) independent and...
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Selected Health Factors (Pulse Pressure, Type 2 Diabetes) and Genetic Polymorphisms (ApoE, IDE rs6583817) Play Independent and Interactive Roles in Patterns of Cognitive Performance and Change in Older Adults
DownloadSpring 2014
Objective: This gene x environment (health) dissertation focused on concurrent and longitudinal change in performance on executive function (EF) and declarative memory (DM) latent variables by normal aging adults. Specifically, we report three studies that tested the independent and interactive...
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Fall 2016
Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer’s disease (AD) and preclinical cognitive and memory decline in older adults. We investigated whether memory resilience to genetic risk (i.e., Apolipoprotein E [APOE] ɛ4, Clusterin [CLU] CC, and a high additive...