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Skip to Search Results- 36Field, Catherine J.
- 29Stothard, Paul
- 20Chan, Catherine B.
- 20Prado, Carla M.
- 19Proctor, Spencer D.
- 19Weselake, Randall J.
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High-performance variants of plant diacylglycerol acyltransferase 1 generated by directed evolution provide insights into structure function
Download2017-09-10
Chen, Guanqun, Vanhercke, Thomas, Chen, Yongyan, Mietkiewska, Elzbieta, Siloto, Rodrigo M. P., Niesner, Nathalie, Xu, Yang, Caldo, Kristian Mark P., Weselake, Randall J., El Tahchy, Anna
Diacylglycerol acyltransferase 1 (DGAT1) catalyzes the acyl-CoA-dependent biosynthesis of triacylglycerol, the predominant component of seed oil. In some oil crops, including Brassica napus, the level of DGAT1 activity can have a substantial effect on triacylglycerol production....
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2010
Siloto, Rodrigo M. P., Weselake, Randall J.
Neutral lipids are ubiquitously found in nature, serving primarily as energy storage compounds. The ability to control the rate of neutral lipid bioassembly is of particular interest in numerous applications. For example, restriction of triacylglycerol and steryl ester synthesis in mammals could...
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2007
Sawhney, Summit, Greiner, Russ, Querengesser, Lori, Shrivastava, Savita, Vogel, Hans J., Arndt, David, Macinnis, Glen D., Natalie, Zhang, Gavin E., Ying, Duggan, Tang, Peter, Amegbey, Godwin, Jewell, Kevin, Wagner, James, Clements, Tzur, Dan, Bamforth, Fiona, Young, Nelson, Miniaci, Jessica, Nikolai, Lisa, Eisner, Roman, Coutouly, Marie-Aude, Clive, Derrick, Li, Liang, Marrie, Tom, Block, David, Hau, David D., Cheng, Dean, Melisa, Gebremedhin, Stothard, Paul, Forsythe, Ian, Weljie, Alim M., Dowlatabadi, Reza, Wishart, David S., Sykes, Brian D., Fung, Chris, Knox, Craig, Jeroncic, Kevin, Mulu, Guo, Lewis, Mike, Guo, An Chi
The Human Metabolome Database (HMDB) is currently the most complete and comprehensive curated collection of human metabolite and human metabolism data in the world. It contains records for more than 2180 endogenous metabolites with information gathered from thousands of books, journal articles...
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2011-01-01
Rowe, David A., Tudor-Locke, Catrine, Hatano, Yoshiro, Schmidt, Michael D., Gardner, Andrew W., Croteau, Karen A., Ewald, Ben, Craig, Cora L., Rogers, Laura Q., Lutes, Lesley D., Bell, Rhonda C., Aoyagi, Yukitoshi, Ramirez-Marrero, Farah A., Tully, Mark A., Matsudo, Sandra M., Blair, Steven N., De Bourdeaudhuij, Ilse
Older adults and special populations (living with disability and/or chronic illness that may limit mobility and/or physical endurance) can benefit from practicing a more physically active lifestyle, typically by increasing ambulatory activity. Step counting devices (accelerometers and pedometers)...
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Identification and expression analysis of WRKY transcription factor genes in Brassica napus (canola) in response to fungal pathogens and hormone treatments
Download2009
Yang, Bo, Rahman, Muhammad H., Deyholos, Michael K., Kav, Nat N. V., Jiang, Yuanqing
Background Members of plant WRKY transcription factor families are widely implicated in defense responses and various other physiological processes. For canola (Brassica napus L.), no WRKY genes have been described in detail. Because of the economic importance of this crop, and its evolutionary...
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Identification of a pair of phospholipid:diacylglycerol acyltransferases from developing flax (Linum usitatissiumum L.) seed catalyzing the selective production of trilinolenin
Download2013
Wickramarathna, Aruna D., Siloto, Rodrigo M. P., Mietkiewska, Elzbieta, Pan, Xue, Weselake, Randall J.
The oil from flax (Linum usitatissimum L.) has high amounts of α-linolenic acid (ALA; 18:3cisΔ9,12,15) and is one of the richest sources of omega-3 polyunsaturated fatty acids (ω-3-PUFAs). To produce ∼57% ALA in triacylglycerol (TAG), it is likely that flax contains enzymes that can efficiently...
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Identification of differentially expressed genes in sexed pig embryos during post-hatching development in primiparous sows exposed to differing intermittent suckling and breeding strategies
Download2016
Chen, Tai Y., Foxcroft, George R., Blanes, Milena, Dyck, Michael K., Athorn, Rebecca, Langendijk, Piete, Tsoi, Stephen
The aim of commercial pig breeding programs is to maximize the number of pigs produced per sow per year. Given that sows exhibit an estrus during lactation is a potential means of increasing productivity of a pig breeding herd without reducing in lactation length, conventionally, weaning of...
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IL-6 indirectly modulates the induction of glyceroneogenic enzmes in adipose tissue during exercise
Download2012
Wan, Zhongxiao, Beaudoin, Marie-Soleil, Castellani, Laura, Wright, David C., Ritchie, Ian, Chan, Catherine B.
Background Glyceroneogenesis is an important step in the control of fatty acid re-esterification with PEPCK and PDK4 being identified as key enzymes in this process. We have previously shown that glyceroneogenic enzymes such as PDK4 are rapidly induced in white adipose tissue during exercise....
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2012
Wan, Zhongxiao, MacDonald, Tara, Wright, David C., Holloway, Graham P., Chan, Catherine B., Perry, Christopher G.
Background Adipose tissue mitochondria have been implicated as key mediators of systemic metabolism. We have shown that IL-6 activates AMPK, a mediator of mitochondrial biogenesis, in adipose tissue; however, IL-6−/− mice fed a high fat diet have been reported to develop insulin resistance. These...
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Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
Download2010
Kuo, Ming-Shang, Dyck, Jason R. B., Sletten, Torunn, Proctor, Spencer D., Jacobs, René L., Lingrell, Susanne, Cao, Guoqing, Peake, David A., Kennedy, Brian P., Zhao, Yang, Vance, Dennis E., Koonen, Debby P. Y., Su, Brian
Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current study investigates whether or not hepatic...