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Skip to Search Results- 1Abou Marak Dit Roum, Darine
- 1Aguilar, Hector N
- 1Al-Momany, Abass M T
- 1Al-Zubaidy, Zaidoon A.
- 1Aljunaidy, Mais
- 1Allan, Douglas Watt
- 5Calcium
- 4Calcium channels
- 4Pregnancy
- 3Aortic aneurysm
- 3Biological transport. Regulation.
- 3Blood-vessels. Dilatation.
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Developmental Programming of Cardiac and Coronary Artery Dysfunction in Adult Male and Female Offspring Exposed to Prenatal Hypoxia
DownloadSpring 2023
Cardiovascular disease is a leading cause of global mortality and a major contributor to morbidity worldwide. Early epidemiological studies demonstrated that pregnancy complications can impact the health of the offspring in adult life. Fetal hypoxia is one of the most common complications of...
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Differential Roles of the Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) in Heart Failure
DownloadFall 2017
Considering the morbidity and mortality associated with heart failure, there is an increasing demand to develop new therapeutic alternatives for cardiac diseases. Advanced left ventricular remodeling following ischemic and pressure-overload cardiomyopathy causes changes in LV geometry, myocyte...
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Differentiation of Primary Human Pro-Fibrotic Mesenchymal Cells Influenced by Extracellular Matrix Environment Determined by MicroRNA Expression
DownloadFall 2018
Fibrosis, a multi-faceted process that exacerbates numerous cardiovascular pathologies leading to heart failure, is the result of excessive extracellular matrix protein deposition. Although fibrosis is classically thought to be the result of myofibroblasts activated from interstitial...
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DNA methylation patterns derived from fetal vulnerability to maternal smoking relate to future child outcomes
DownloadSpring 2021
Fetuses exposed to maternal smoking during pregnancy (MSP) are at higher risk of developing illnesses such as obesity, diabetes and heart, lung and mental health disease. These disorders are part of a group of non-fatal, non-communicable common complex diseases (CCDs) that form the greatest...
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Spring 2014
With matrix metalloproteinases-2 (MMP2) deficiency, we observed thoracic aortic aneurysm in 70% of MMP2-/- mice but no abdominal aortic aneurysm following four weeks of angiotensin II (Ang II) infusion. We found markedly suppressed recoil properties in the thoracic aorta of MMP2-/-- Ang II mice....
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Fall 2017
The pathological events initiating diabetic cardiac changes in response to chronic hyperglycemia and hyperinsulinemia remain unclear. Due to the high metabolic activity of the heart, and its sensitivity to acute changes in oxygen and substrate flux, mitochondrial dysfunction has been proposed as...