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Silencing immunoglobulin gene enhancers as a potential treatment strategy for multiple myeloma
DownloadFall 2009
Multiple myeloma is a bone marrow malignancy characterized by the presence of monoclonal plasma cells. In 50-75% of myeloma patients, chromosome translocations at the IgH locus are observed, which result in overexpression of oncogenes from the translocated chromosome due to linkage with the IgH...
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Fall 2014
The purpose of this work is to understand properties of skeletal muscle of cancer patients experiencing severe muscle depletion. These studies were done using computed tomography (CT) imaging and patient information (demographics), and collection of muscle biopsies to analyze using flow...
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Skin Dose in Longitudinal and Transverse Linac-MRIs using Monte-Carlo and realistic 3D MRI field models
DownloadSpring 2013
Keyvanloo Shahrestanaky, Amirmohamad
The integration of a clinical linear accelerator (linac) with a magnetic resonance imaging (MRI) system would provide real-time tumor tracking. The magnetic fields of linac-MR systems modify the path of contaminant electrons in photon beams, which alters patient skin dose. In this work, we used...
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Spectral Editing for Detection of Oncologically Relevant Metabolites with In-Vivo Magnetic Resonance Spectroscopy at 9.4 T
DownloadFall 2019
Short echo time (TE) magnetic resonance spectroscopy (MRS) techniques with spectral fitting are commonly employed approaches for brain metabolite quantification at 9.4 T. However, there is a significant overlap of peaks in short-TE spectra, even at 9.4 T. To better resolve resonances, spectral...
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Spring 2018
Modern effort in radiotherapy to address the challenges of tumor localization and motion has led to the development of MRI guided radiotherapy technologies. Accurate dose calculations must properly account for the effects of the MRI magnetic fields. St-Aubin et al. (2015, 2016) have investigated...
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Streamline Upwind Petrov-Galerkin Angular Stabilization of the Linear Boltzmann Transport Equation with Magnetic Fields
DownloadSpring 2020
Dose modelling is an important component of radiotherapy treatment planning, as clinicians prescribe a dose to a tumour while requiring certain adjacent organs to receive at or below a given tolerance dose. Mathematical models such as the linear Boltzmann transport equation, or LBTE, provide a...
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Fall 2015
Mitosis is the last and the shortest stage of the cell cycle with the ultimate goal of equal distribution of replicated genetic material into two daughter cells. Proper execution of mitosis is very important for the maintenance of genomic integrity. Failure of the accurate segregation of genetic...
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Fall 2013
Cancer cachexia is a multifactorial syndrome characterized by involuntary weight loss, wasting of skeletal muscle driven by reduced food intake and abnormal metabolism. Cachexia has a negative impact on quality of life, response to chemotherapy and survival. Cachexia research is undeveloped with...
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Fall 2018
Magnetic resonance imaging (MRI) can visualize solid tumours in real time and its integration with a linear accelerator offers the possibility to track tumours during irradiation. However, irradiating a patient inside a linac-MR poses several challenges. MRI uses radiofrequency (RF) coils to...