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Skip to Search Results- 2Jutras, Jean-David
- 2Yip, Eugene
- 1Abdou, Ismail
- 1Adamia, Sophia
- 1Alaee, Mahsa
- 1Anderson, Danielle L.
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Fall 2018
Colchicine is an anti-mitotic drug that targets unpolymerized tubulin, and inhibits microtubule polymerization. It is primarily used to treat gout but has been investigated in numerous clinical trials to treat conditions such as leukemia (ALL), prostate cancer, and inflammatory diseases. However,...
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma Receptors
DownloadSpring 2019
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
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The Role of the Androgen Receptor in Prostate Cancer-induced Platelet Aggregation and Invasion
DownloadFall 2019
Background: Prostate cancer (PCa) is the most common visceral malignancy and third leading cause of cancer death among men in Canada. The 2018 Canadian Cancer Society estimates suggest that 21,300 men were diagnosed and 4,100 patients died of this disease. Metastatic prostate cancer (mPCa) is...
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4-[18F]Fluoroiodobenzene and its applications in palladium-mediated Sonogashira cross coupling reactions
DownloadFall 2014
Way, Jenilee1; Wang, Monica1; Wuest, Melinda1; Bergmann, Cody1; Hamann, Ingrit1; Wuest, Frank1* 1 University of Alberta, Department of Oncology, Edmonton, Alberta, Canada The ongoing demand for novel 18F-labelled radiotracers is frequently accompanied with the need to develop novel...
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Spring 2013
Polycomb protein methyltransferase, Enhancer of Zeste 2 (Ezh2), is frequently overexpressed in human malignancy and is implicated in cancer cell proliferation and invasion. Recently, several other polycomb proteins have been implicated in modulating the response to DNA double strand breaks, and...
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Accurate Dosimetry for Ocular Brachytherapy: Measurement, Delivery Uncertainty, and Dose Calculation Studies
DownloadFall 2017
Ocular brachytherapy has been found to be an excellent alternative for the treatment of ocular melanomas compared to the predominantly used treatment prior to the 1980s of enucleation. Tumour control rates are generally >90%, overall survival rates are equivalent to enucleation, and ocular...
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Anti-cancer effects of n-3 long-chain polyunsaturated fatty acids (LCPUFA) on ovarian cancer growth in vitro and in vivo
DownloadFall 2019
Objectives: Many ovarian cancer (OC) patients relapse with chemo-resistant disease, necessitating improved therapeutic approaches. Recent studies have determined that long chain polyunsaturated fatty acids (LCPUFA) may affect cancer cell growth and metastatic potential; however, few studies have...
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Automatic Optimization of Treatment Dosimetry to Improve Visual Outcomes in Episcleral Plaque Brachytherapy
DownloadFall 2019
Ocular plaque brachytherapy is an effective treatment option for medium-sized ocular melanomas, showing equivalent survival relative to enucleation, while providing added benefits of eye preservation and possible vision retention. Currently the treatment planning system for plaque brachytherapy,...