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Spring 2019

McNamara, Allison M

Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...

Fall 2019

Hamedi, Bahareh

Objectives: Many ovarian cancer (OC) patients relapse with chemo-resistant disease, necessitating improved therapeutic approaches. Recent studies have determined that long chain polyunsaturated fatty acids (LCPUFA) may affect cancer cell growth and metastatic potential; however, few studies have...

Fall 2017

Kazemi Bajestani, Seyyed Mohammad Reza

Background: Cancer cachexia is referred to as a wasting condition, with skeletal muscle and fat loss. Although heart atrophy is recognized as a notable component of experimental cancer cachexia models, it has not been characterized in human studies. The contribution of cardiac structural and...

Spring 2018

Leier, Samantha A

Achieving chemoselectivity while maintaining bioorthogonality are among some of the major challenges in bioconjugation chemistry. Bioconjugation chemistry has important applications in PET radiochemistry. While modern bioconjugation techniques rely predominantly on lysine and cysteine residues...

Spring 2020

Yang, Ray

Accurate and efficient patient dose calculation for Magnetic Resonance Imaging (MRI)-guided Radiotherapy is pursued based on a deterministic solution to the Linear Boltzmann Transport Equation (LBTE) with magnetic fields, as a technique which does not suffer from statistical uncertainty, and...

Fall 2017

Kadam, Alisha

Epidermal Growth Factor-like domain 7 (EGFL7) is a secreted angiogenic factor that is almost exclusively expressed by endothelial cells. High EGFL7 expression occurs during physiological angiogenesis, under pathological conditions, and in solid tumor angiogenesis. Evidence suggests that EGFL7...

Spring 2020

Krys, Daniel

Positron Emission Tomography (PET) utilizes radioactively tagged molecules to identify cancerous tissue. In most cases, membrane transporters control entry of these molecules into human cancer cells. Hypoxia-inducible factor (HIF)-1 is the master homeostatic regulator during hypoxia in human...

Fall 2019

Pattabhi Raman, Sindhuja

Solid tumors often have large areas with low levels of oxygen (termed hypoxic regions), which are associated with poor prognosis and treatment response. Tirapazamine (TPZ), a hypoxia targeting anticancer drug, started as a promising candidate to deal with this issue. However, it was withdrawn...

Fall 2018

Alaee, Mahsa

Plakoglobin (γ-catenin) is an Armadillo protein family member and a paralog of β-catenin with similar dual cell-cell adhesion and signaling activities. These proteins interact with cadherins at the membrane and mediate cell-cell adhesion. In the cytoplasm, they interact with an array of cellular...

Spring 2020

Dinakaran, Deepak

Radiotherapy is used in the treatment of 50% of all cancer patients. It has evolved into a high precision therapy in cancer care. Radiotherapy’s main limitation is the damage incurred on normal tissue. Advances in modern radiotherapy allowed for improved precision in delivery and optimizes its...