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Fall 2018

Clayton James Bell

Colchicine is an anti-mitotic drug that targets unpolymerized tubulin, and inhibits microtubule polymerization. It is primarily used to treat gout but has been investigated in numerous clinical trials to treat conditions such as leukemia (ALL), prostate cancer, and inflammatory diseases. However,...

Spring 2019

McNamara, Allison M

Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...

Fall 2019

Jan K Rudzinski

Background: Prostate cancer (PCa) is the most common visceral malignancy and third leading cause of cancer death among men in Canada. The 2018 Canadian Cancer Society estimates suggest that 21,300 men were diagnosed and 4,100 patients died of this disease. Metastatic prostate cancer (mPCa) is...

Fall 2014

Way, Jenilee D

Way, Jenilee1; Wang, Monica1; Wuest, Melinda1; Bergmann, Cody1; Hamann, Ingrit1; Wuest, Frank1* 1 University of Alberta, Department of Oncology, Edmonton, Alberta, Canada The ongoing demand for novel 18F-labelled radiotracers is frequently accompanied with the need to develop novel...

Spring 2013

Campbell, Stuart D.

Polycomb protein methyltransferase, Enhancer of Zeste 2 (Ezh2), is frequently overexpressed in human malignancy and is implicated in cancer cell proliferation and invasion. Recently, several other polycomb proteins have been implicated in modulating the response to DNA double strand breaks, and...

2004

Maxwell, Christopher A

Fall 2017

Morrison, Hali A.E.K.

Ocular brachytherapy has been found to be an excellent alternative for the treatment of ocular melanomas compared to the predominantly used treatment prior to the 1980s of enucleation. Tumour control rates are generally >90%, overall survival rates are equivalent to enucleation, and ocular...

Fall 2013

Sharon, David

Hepatocellular carcinoma (HCC) is the fifth most common cancer and third leading cause of cancer-related deaths. Due to the low response to current HCC therapy, many studies have been done to identify novel HCC therapeutics. Non-replicating first generation adenovirus (Ad) vectors and...

Fall 2019

Hamedi, Bahareh

Objectives: Many ovarian cancer (OC) patients relapse with chemo-resistant disease, necessitating improved therapeutic approaches. Recent studies have determined that long chain polyunsaturated fatty acids (LCPUFA) may affect cancer cell growth and metastatic potential; however, few studies have...

Fall 2019

Han, Gawon

Ocular plaque brachytherapy is an effective treatment option for medium-sized ocular melanomas, showing equivalent survival relative to enucleation, while providing added benefits of eye preservation and possible vision retention. Currently the treatment planning system for plaque brachytherapy,...