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Fall 2018

Wong, Jason A.J.

A global prophylactic vaccine for Hepatitis C Virus (HCV) remains elusive. The diversity of the virus is a major hurdle; a successful vaccine will need to protect against all 7 HCV genotypes (gt). Our lab is developing a vaccine comprising the two envelope glycoproteins of HCV (E1E2). An...

Fall 2014

Colpitts, Che C

Viral entry is an attractive antiviral target. Entry inhibitors prevent infection of healthy cells and inhibit viral replication before viruses establish persistent reservoirs. Two entry steps, the primary attachment to cellular glycans and the lipid rearrangements during fusion, are conserved...

Fall 2015

Lehman, Bettina, J

Many cellular processes are regulated by the ubiquitin proteasome system (UPS), which utilizes the polypeptide ubiquitin to mark proteins for destruction via the 26S proteasome. Since the UPS plays an important role in cellular homeostasis, many viruses have evolved strategies to regulate the...

2006

Skipper, Vashni Elise

Fall 2024

May, Julia F.

The stochastic diversification of the T cell receptor (TCR) carries with it both the potential for recognizing virtually infinite foreign peptides, but also the potential for the erroneous recognition of self-peptides, which represents a threat of autoimmunity. During development in the thymus, T...

Fall 2016

Suen, Alexander YW

T cells are part of the adaptive immune system that eliminate pathogen-infected cells, but do not harm healthy cells. Precursor T cells, termed thymocytes, develop in the thymus where they randomly generate and express unique antigen specific T cell receptors (TCR) during the CD4+CD8+ double...

Fall 2018

Gavina, Kenneth C

Malaria caused by the genus Plasmodium (P.) is one of the oldest and most important parasitic infections globally. Pregnant women are at an increased risk for malaria, where the disease poses a significant risk to both maternal and child health. Better diagnosis of malaria can have an immediate...

2000

Li, Zhi

Fall 2019

McKenzie, Brienne Alexandra Furfaro

Multiple sclerosis (MS) is a progressive and incurable demyelinating disease of the central nervous system (CNS). The neuropathogenesis of MS and its prototypic animal model, experimental autoimmune encephalomyelitis (EAE), is defined by persistent neuroinflammation, involving the activation of...

Spring 2013

Hockley, Deanna L

The adaptive immune response against intracellular pathogens is largely mediated by CD8+ T lymphocytes. The clonal expansion and expression of cytolytic and immune stimulatory proteins by CD8+ T cells is responsible for their protective immune function. Prior to exhibiting effector activity,...