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Skip to Search Results- 1Ayoub, Ahmed T
- 1Bau, Jeremy A
- 1Bhakta, Urmi Bhusan
- 1Churchill, Cassandra D.M.
- 1Coumont, Leah Shawn
- 1Dezhahang, Zahra
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A fluorescent protein exchange strategy for detecting protein-protein interactions and discovering proteinaceous inhibitors in Escherichia coli
DownloadFall 2015
Enterina, Jhon Ralph De La Peña
Green fluorescent protein (GFP), along with other GFP-like proteins, is one of the fundamental tools that are enabling the exciting current era of biological studies. The utility of GFP-like proteins as genetically encoded markers and sensors has provided us with powerful tools for tracking...
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A path towards better cancer drugs: Modeling interactions between antimitotic agents and tubulin
DownloadFall 2015
Antimitotic agents, a class of cancer chemotherapies, target the tubulin protein in microtubules to suppress microtubule dynamics and affect the segregation of chromosomes during cell division. A variety of antimitotic agents are known, which range in status from clinically-approved agents to...
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Fall 2015
α-Synuclein is a protein that has been found as fibrillar aggregates in Lewy bodies in the brain of Parkinson’s disease patients. Though the cause of the Parkinson’s disease is unknown, previous research suggest that there is a close association between the disease and the toxicity of the...
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Fall 2015
2015 marks the 50th anniversary of Moore's law, which has described the exponential progress in semiconductor patterning technologies, enabling creation of smaller circuitry features at greater densities. These continued hardware developments, economically mass manufactured, have made possible...
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Application of Electrospray Ionization Mass Spectrometry to Study Protein-Ligand Interactions and Enzyme Kinetics
DownloadFall 2015
This thesis describes the development and application of electrospray ionization mass spectrometry (ESI-MS) to study the noncovalent protein-ligand interactions and also investigate the kinetic of enzymatic reactions. The rate of glycolipids cleavage by the human neuraminidase 3 (hNEU3) was...
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Breaking New Ground with the Suzuki-Miyaura Reaction: Stereoselective Cross-Couplings of 1,1-Diboronyl Alkanes
DownloadFall 2015
Synthetic organic chemistry is an area that has seen incredible growth through the years. The level of molecular complexity that can be achieved through available synthetic methods today is remarkable. Still, as the field continues to progress, increasing focus is being placed upon the strategic...
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Fall 2015
Capillary electrophoresis (CE) is a powerful separation technique. The analysis of inorganic ions using capillary electrophoresis is becoming increasingly recognized for its high resolving power, low cost, and the simplicity of design, optimization, and execution of CE experiments. To achieve...
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Carbohydrate-Modified Microgels as a System for Extracting Naphthenic Acids from Tailings Pond Water
DownloadFall 2015
Northern Alberta houses massive tailings ponds, that store aqueous waste as a result of the processes employed to recover bitumen from the oil sand deposits. The aqueous waste, or tailings pond water (TPW), houses numerous toxic chemicals including naphthenic acids (NAs) - a complex group of...
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Spring 2015
The objective of this work was to employ differential 13C/12C dansyl chloride (DnsCl) derivatization strategies for qualitative and quantitative profiling of amine- and phenol-containing metabolites by liquid chromatography electrospray ionization Fourier Transform ion cyclotron resonance mass...
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Computational Investigations on Excited State Properties of Cyanine Dyes and Carbene-bound Main Group Elements
DownloadFall 2015
The first section of this thesis is concerned with the computational study of excited state properties of boron-dipyrromethene (BODIPY) organic dyes using ab initio and time-dependent density functional theory (TD-DFT) methods. Through a comprehensive benchmark of TD-DFT methods against...