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Skip to Search Results- 33Mass-spectrometry
- 24Chemistry
- 23Organic compounds. Synthesis.
- 22Metabolomics
- 21Capillary electrophoresis.
- 21Catalysis
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Studies Towards Understanding the Biosynthesis of Methyl Phosphoramidates found in Campylobacter jejuni
DownloadFall 2016
The human pathogen Campylobacter jejuni is the leading cause of food-borne gastroenteritis, causing more foodborne illnesses than Salmonella, Shigella, and Listeria combined. Of the approximate 5.3 million people infected every year in North America alone, approximately 1/1000 will develop the...
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Studies Undertaken Towards the Total Synthesis of Antifreeze Compounds Based on the Xylomannan Antifreeze from the Alaskan Beetle Upis ceramboides
DownloadFall 2019
Biological antifreeze substances are widely found in the tissues of cold-blooded organisms indigenous to polar environments. Prior to 2009, all these compounds were associated with protein, leading to the widespread assumption that all biological antifreeze substances must possess a protein or...
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Study of Non-Covalent Multisubunit Protein-Carbohydrate Interactions by Electrospray Ionization Mass Spectrometry
DownloadFall 2013
This thesis describes the development and application of electrospray ionization mass spectrometry (ESI-MS) based techniques to investigate protein-carbohydrate interactions in vitro. A catch-and-release electrospray ionization mass spectrometry (CaR-ESI-MS) assay was developed for the...
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Study of Non-Covalent Protein-Carbohydrate Interactions using Electrospray Ionization Mass Spectrometry
DownloadFall 2012
This thesis describes the development and application of electrospray ionization mass spectrometry (ESI-MS) methods to study protein-carbohydrate interactions in vitro. The affinities (Ka) of two recombinant fragments of Clostridium difficile toxins (TcdA & TcdB) and a library of the most...
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Study of Non-Covalent Protein-Carbohydrate Interactions by Nanoelectrospray Ionization Mass Spectrometry and Surface Plasmon Resonance
DownloadFall 2015
This thesis describes the application of electrospray ionization mass spectrometry (ESI-MS) techniques to identify and quantify antibody-antigen interactions in vitro. Also potential application of nanodiscs (ND) as membrane model in ESI-MS and surface plasmon resonance (SPR) spectroscopy has...
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Spring 2014
My PhD thesis work is centered on developing a suitable approach to account for solvent effects in solution spectroscopic measurements and on providing significant insights into the intermolecular interactions between chiral solute and solvent, in particular water, molecules. Vibrational...