Search
Skip to Search Results- 2Lohmeier, Elke Monika, 1955-
- 2Veldhoen, Richard
- 1ALSHUMAIMERI, NADA A.
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
-
Fall 2012
Chromatin structure is important aspect of transcriptional regulation. Replication-coupled (RC) nucleosome assembly is the process of depositing newly synthesized H3-H4 onto nascent DNA behind the replication fork, mediated by the histone chaperones Asf1, CAF-1, and Rtt106. The experiments...
-
New insights into the N-end Rule Pathway: from the substrate recognition to its selective inhibition
DownloadFall 2019
The N-end rule represents a crucial proteolytic pathway which regulates in vivo half-life of a protein by the identity of its N-terminal residues. As such, the instability of the substrate is conferred by the ability of the cellular machinery to recognize the N-terminal amino acid and target the...
-
Novel Isotope Labeling Strategies for NMR-Based Structure Determination of High Molecular Weight Proteins
DownloadSpring 2023
Solution NMR studies of high molecular weight proteins suffer from inadequate side-chain information and rapid signal decay. Selective 1H, 13CH3-methyl labelling of perdeuterated proteins has been the standard approach addressing these limitations but suffers from a lack of information about the...
-
Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
-
Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...