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- 6Transcription factors
- 1Anterior segment dysgenesis
- 1Brain fatty acid-binding protein
- 1Brain tumour
Forkhead (Fox) proteins are transcription factors that function in many processes including development, metabolism and cell cycle regulation. This gene family is divided into subfamilies that appear to originate from a common ancestor. I have identified the evolutionary selection pressures...
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...
Preliminary validation of a computer-based approach to find new lead molecules targeting the oncogenic Forkhead box M1 transcription factorDownload
The upregulation of the forkhead box M1 (FOXM1) transcription factor is directly correlated with cancer initiation, invasion, and drug resistance. Because the overexpression of FOXM1 is considered an important factor in carcinogenesis, this protein could be a relevant drug target in cancer...
Development of the vertebrate central nervous system is a complex process that relies on the accurate spatiotemporal distribution of signaling centers during embryogenesis. These signals provide cells with positional information, which is integrated via transcription factors and gene regulatory...
DNA strand displacement reaction (SDR) is a fast, isothermal, and sequence specific reaction. In SDR, an invading DNA single strand, also known as the “fuel” strand, unzips a partial duplex to form a more thermodynamically stable duplex. The complementary strand to the fuel strand is referred to...
Development of progenitor cells into myeloid cells (i.e. macrophages and neutrophils) is critical to the survival of metazoans for maintenance of homeostasis and defense against pathogens. While much is known about myeloid cell development in mammals, less is known about this process in fish. The...