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Fall 2012
Establishing mixed hematopoietic chimerism is a promising approach to develop donor-specific tolerance to transplanted organs. Establishing tolerance may eliminate the need for long-term immunosuppressive therapy, prevent chronic rejection and in the case of Type 1 Diabetes (T1DM), reverse...
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Developing clinically translatable chimerism induction protocols in a stringent murine model
DownloadSpring 2020
Allogeneic hematopoietic chimerism induction via bone marrow transplantation (BMT) is thus far the most robust method for inducing donor antigen specific tolerance to allogeneic grafts. However, limited by the toxicity of the reagents used in conditioning the recipients, the demand of a high dose...
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Fall 2011
The main function of co-inhibitory molecules is to regulate T cell immune responses by providing negative signals to those cells. Homeostatic activation of T cells occurs in both natural and artificially induced states of lymphopenia. Although lymphopenia leads to homeostatic proliferation of T...
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Tolerance to neonatal porcine islet xenografts induced by a combination of monoclonal antibodies
DownloadFall 2009
Islet transplantation is a more physiological way to treat type 1 diabetes. However, shortage of donor tissue and chronic administration of immune suppressive drugs has limited the widespread application of this therapy for all patients with type 1 diabetes, particularly children suffering from...