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- 5Neonatal porcine islets
- 3Islet transplantation
- 2Islet xenotransplantation
- 1Anti-CD154 monoclonal antibody
- 1Anti-CD45RB monoclonal antibody
Mesenchymal stem cells (MSCs) have immuno-regulatory, anti-inflammatory, and pro-angiogenic properties through the secretion of a myriad of trophic factors, and have been shown to have a beneficial effect on graft function. In this thesis we investigated whether MSCs’ have an effect on neonatal...
Co-transplantation of neonatal porcine islets with Sertoli cells combined with short-term monoclonal antibody therapy in preventing neonatal porcine islet xenograft rejectionDownload
The need for an unlimited source of islets and a safer method of immunosuppression has limited the widespread application of islet transplantation. To remedy the shortage of donor tissue, xenotransplantation of neonatal porcine islets (NPI) has been proposed. In this study we sought to determine...
Islet transplantation is an attractive method to achieve blood glucose homeostasis. However, β-cell function declines over time. Therefore, it is necessary to explore strategies to enhance the β-cell mass and function. Also, because there is a severe shortage of human cadaver tissue, alternative...
Islet transplantation is a more physiological way to treat type 1 diabetes. However, shortage of donor tissue and chronic administration of immune suppressive drugs has limited the widespread application of this therapy for all patients with type 1 diabetes, particularly children suffering from...
The development of the Edmonton protocol was an important milestone in the process of establishing islet transplantation as a cure for diabetes. However, many challenges must still be overcome, including the shortage of donor organs. To address this issue, we believe that neonatal porcine islets...