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Skip to Search Results- 1Askar, Abdelrahman Mostafa Mohamed Sanad
- 1Bhattacharya, Amit
- 1Breitkreutz, Dylan Y
- 1Fu, Zelin
- 1Ha, Michelle
- 1Harris, Kristopher J.
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Spring 2023
For more than 70 years, chemists have used Nuclear Magnetic Resonance (NMR) spectroscopy to characterize the atomic structure and dynamics of molecules. Key to performing the NMR analysis of almost any molecule is a process called “chemical shift assignment”. This involves matching specific peaks...
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Fall 2009
This thesis is concerned with applications of modern solid-state NMR spectroscopy. Investigations of three quite different types are undertaken, each of which attempt to advance knowledge in the fields of chemistry and NMR. The goal of each project is to obtain insight into the effects of...
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Structural aspects of the interaction of the cytoplasmic domain of Mucin-1 (MUC1) with the SH3 domain of Src Kinase
DownloadFall 2011
Marasinghe Arachchige, Bodhi Nirosha
Abstract Breast cancer is the second most frequent cause of cancer deaths in Canadian women with death resulting from the spread of cancer cells or metastasis to distal organs. Our laboratory was the first to show that MUC1, a type-1 transmembrane glycoprotein highly overexpressed in breast...
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Structure and dynamics of biomolecules: probing muscle regulation, prion protein unfolding, and drug insertion into DNA by nuclear magnetic resonance spectroscopy
DownloadSpring 2011
Nuclear magnetic resonance (NMR) spectroscopy is a powerful approach to study the structure and dynamics of macromolecules in a close-to-native solution environment. In the present thesis I present my investigation of protein and nucleic acid structure and dynamics in a wide variety of biological...
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Study of Methylammonium Lead Triiodide Intrinsic Stability and Solid-Solution behaviour in Mixed Halide Perovskite Systems
DownloadFall 2018
Askar, Abdelrahman Mostafa Mohamed Sanad
Over the last nine years, a new class of materials named lead halide perovskite has made a paradigm shift in the field of optoelectronic solution-processable low-cost and high-efficiency devices, with outstanding accomplishments especially in the ever-growing field of renewable solar energy...
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Using 1H-NMR based metabolomics to investigate the pathological consequences of mitochondrial disease and human rabies infection
DownloadSpring 2012
Mitochondrial diseases encompass a wide range of clinical phenotypes. The etiology of these disorders is extremely complex; mitochondria are central to energy metabolism and dysfunction can have a profound effect on global metabolism. The original objective of this thesis was to use 1H-NMR based...