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An investigation of factors that regulate cytoskeleton in the first mitotic division of the C. elegans embryo
DownloadFall 2017
Microtubule dynamics is regulated by naturally occurring microtubule-associated proteins occurring in the cellular environment as well as by natural and synthetic compounds. These compounds target the microtubule cytoskeleton and serve as anti-mitotic drugs. Therefore, microtubules continue to be...
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Characterization of GBF1, Arfs and COPI at the ER-Golgi intermediate compartment and mitotic Golgi clusters
DownloadFall 2009
Protein trafficking between the endoplasmic reticulum (ER) and Golgi complex is regulated by the activity of ADP-ribosylation factors (Arfs). Arf activation by guanine nucleotide exchange factors (GEFs) leads to the recruitment of the coatomer protein COPI and vesicle formation. By using...
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Fall 2009
One form of protein regulation is accomplished by post-translational modification (PTM). In order to test the importance one type of PTM, methylation, in chromosome segregation, we inhibited protein methylation for brief periods in G2 using the general methylation inhibitor adenosine dialdehyde...
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Spring 2015
Spindle assembly pathways are conserved in many organisms. Defects in spindle assembly can result in aneuploidy, a common cause of cell death and cancer. A better understanding of spindle assembly pathways is required to fully appreciate how defects in spindle assembly manifest as aneuploidy and...
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Fall 2021
The mitotic checkpoint is a failsafe mechanism for the cell to ensure correct chromosome segregation. The evolutionarily conserved kinetochore RZZ complex is an essential component of the mitotic checkpoint. Spindly interacts with the RZZ complex in a farnesylation dependent manner and acts as a...
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Fall 2015
Mitosis is the last and the shortest stage of the cell cycle with the ultimate goal of equal distribution of replicated genetic material into two daughter cells. Proper execution of mitosis is very important for the maintenance of genomic integrity. Failure of the accurate segregation of genetic...
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The Drosophila GW protein, a posttranscriptional gene regulator that influences progression through mitosis
DownloadSpring 2010
Regulation of mRNA translation and stability can occur in cytoplasmic compartments known as mRNA processing bodies or P bodies. These compartments contain factors that function in multiple mRNA regulatory pathways and are thought to be centres for coordinating the action of these pathways. One...