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Biochemical investigations of two polyketide synthase subclasses – highly reducing/non-reducing pairs, and polyketide synthase non-ribosomal peptide synthetases.
DownloadSpring 2016
Cladosporin is a polyketide metabolite that is biosynthesized by a highly reducing (HR)/non-reducing (NR) polyketide synthase (PKS) pair, wherein they catalyse head-totail condensation of acetyl and malonyl CoA units with subsequent β-keto modification. Cladosporin has recently been reported as a...
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Inhibition Studies of DapL Enzymes Orthologs and Synthesis of Proposed Biosynthetic Intermediates of Tabtoxin and Synthesis of a Hexaketide as a Standard for Lovastatin Studies
DownloadFall 2017
The enzyme LL-diaminopimelate aminotransferase (DapL) catalyzes the transformation of L-THDP to LL-DAP during the biosynthesis of lysine in plants, alga, and in some pathogenic bacteria like Leptospira interrogans and Verrucomicrobium spinosum. Because the biosynthesis of lysine is absent in...
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Investigation of the biosynthesis of lovastatin and cytochalasin E, two fungal polyketides assembled by iterative PKS-NRPS enzymes
DownloadFall 2015
Cytochalasin E and lovastatin are two fungal polyketides that have seen extensive use as an angiogenesis inhibitor and as a cholesterol-lowering agent, respectively. These structurally divergent compounds are synthesized by polymerization of acetate units with concomitant functionalization by two...
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Investigations of Fungal Highly Reducing Polyketide Synthases: The Biosyntheses of Lovastatin and Hypothemycin
DownloadFall 2017
Fungal highly reducing polyketide synthases (HR-PKSs) are large, multi-domain enzymes central to the biosynthesis of fungal polyketides. They assemble complex secondary metabolites, called polyketides, through the condensation of two-carbon acetate units and tailoring of the functional groups at...