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Skip to Search Results- 1Barley, Randall Douglas Corwyn
- 1Bornes, Troy D.
- 1Chapman, David W
- 1Elezzabi, Muhammad A.
- 1Jalubula, Venkatesh
- 1Kits, Kerim D
- 4Department of Surgery
- 3Centre for Neuroscience
- 3Department of Oncology
- 2Department of Physiology
- 1Department of Biological Sciences
- 1Department of Medicine
- 2Wuest, Frank (Oncology)
- 1Adesida, Adetola (Department of Surgery
- 1Adesida, Adetola B. (Surgery)
- 1Afsaneh Lavasanifar, Faculty of Pharmacy and Pharmaceutical Sciences
- 1Davidge, Sandra T. (Physiology/Obstetrics and Gynecology)
- 1Dr. Keith M. Bagnall, Department of Anatomy, United Arab Emirates University
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Pre-clinical Evaluation of Iodoazomycin Arabinofuranoside (IAZA) and Fluoroazomycin Arabinofuranoside (FAZA) as Hypoxia-targeting Therapeutic Agents in a Head and Neck Cancer Model
DownloadSpring 2022
Tumour hypoxia is a well-recognized clinical problem that promotes resistance to anti-cancer treatment (chemotherapy, radiotherapy, and immunotherapy), increases rates of recurrent disease, and ultimately leads to poor patient outcome. Eradication of hypoxic tumours is, therefore, essential for...
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Spring 2016
The hypoxic ventilatory response comprises of an initial increase in ventilation, followed by a secondary depression that can be life threatening in premature infants. During hypoxia, ATP is released in the ventrolateral medulla, where it is suggested to attenuate the secondary hypoxic...
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Rational Design and Development of Nanodelivery Systems and Combination Treatments for Overcoming Chemoresistance in Solid Tumors
DownloadFall 2017
The long term goal of this research is to develop drug delivery systems and combination treatments that can overcome chemoresistance in breast cancer. Here, we attempted two different approaches: First, we tried development of polymeric micelles capable of enhanced drug delivery to tumor, while...
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Fall 2016
Articular cartilage injury is a major risk factor for the development of osteoarthritis, a condition that results in significant patient morbidity and substantial cost to the healthcare system. Due to the limited capacity of articular cartilage to regenerate, early intervention is required to...
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Fall 2013
Glomus cells of the carotid body are peripheral chemoreceptors that detect changes in arterial oxygen levels. Hypoxia suppresses oxygen-sensitive K+ channels in glomus cells, resulting in cytosolic Ca2+ ([Ca2+]i) elevation in glomus cells via the activation of voltage-gated Ca2+ channels. The...
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The Effect of Inhaled Nitric Oxide on Maximal Oxygen Consumption During Exercise in Hypoxia.
DownloadFall 2021
Background and Rationale. Arterial hypoxemia (decreased arterial oxygen content [CaO2]) caused by a decrease in inspired partial pressure of oxygen (PIO2), can result in a similar reduction in exercise capacity as observed in chronic lung disease. Literature has suggested a discrepancy in the...
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Utilizing Positron Emission Tomography to Detect Functional Changes Following Drug Therapy in a Renal Cell Carcinoma Mouse Model
DownloadSpring 2013
Sunitinib is currently the first line drug therapy for metastasizing renal cell carcinoma (RCC). It has been shown to have a profound effect on tumor angiogenesis leading to modifications of the tumor’s microenvironment. Tumor hypoxia plays an important role in the metastatic potential of a solid...