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- 1Alavi, Parnian
- 1Barley, Randall Douglas Corwyn
- 1Bornes, Troy D.
- 1Chapman, David W
- 1Danylchuk, A.
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Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: A hypoxia specific mechanism of actionDownload
Angiostatin is an angiogenesis inhibitor in part generated by and released from platelets. Since platelets upon thrombus formation can give rise to areas of hypoxia, we investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular...
Collagen I: an aberrantly expressed molecule in chondrocytes or a key player in tissue stabilization and repair both in vivo and in vitro?Download
Extrinsic repair techniques for the treatment of acute chondral injuries continue to yield suboptimal repair. The inability of these techniques to produce hyaline cartilage underscores the limitations in our understanding of basic chondrocyte biology. Conversely, intrinsic repair tissue has not...
Aerobic methanotrophic bacteria lessen the impact of the greenhouse gas methane (CH4) not only because they are a sink for atmospheric methane but also because they oxidize it before it is emitted to the atmospheric reservoir. Aerobic methanotrophs, unlike anaerobic methane oxidizing archaea,...
Microglia, the resident immune cells of the central nervous system (CNS), become activated in response to danger signals given out by other cells when homeostasis has been disturbed. Microglial activation is a multifaceted phenomenon that includes numerous distinct phenotypes. The type of...
Cardiovascular and metabolic diseases are still the primary cause of death and disability in modern society. Although genetic factors play a fundamental role in the development of these chronic conditions, the remarkable variability in an individual’s susceptibility to develop these pathologies...
Molecular mechanisms involved in P2Y1 receptor-mediated excitation of the inspiratory rhythm generating networkDownload
Hypoxic ventilatory response is biphasic, comprising of an initial increase in ventilation followed by secondary depression. Initial increase in ventilation is mediated by peripheral carotid bodies where as central mechanisms were implicated in secondary depression. The secondary depression phase...
Natural disturbances and fish: Local and regional influences on winterkill of fathead minnows, Pimephales promelas, in boreal lakesDownload
We investigated the population dynamics of fathead minnow Pimephales promelas and the environmental factors of four small lakes in the boreal forest of Alberta, Canada, for 5 years to determine the influence of local and regional factors on the development of hypoxia and the occurrence of fish...
Introduction: The sympathetic nervous system is the primary regulator of the "fight or flight" response, with muscle sympathetic nerve activity (MSNA) increasing in response to various stressors, including low oxygen (hypoxia; HX). MSNA is an important regulator of cardiovascular function,...
The hypoxic ventilatory response comprises of an initial increase in ventilation, followed by a secondary depression that can be life threatening in premature infants. During hypoxia, ATP is released in the ventrolateral medulla, where it is suggested to attenuate the secondary hypoxic...