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- 1DNA damage
- 1Fluorescence
- 1Fluorescence sensor
- 1Molecular beacons
- 1Nucleic acid damage
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Spring 2012
In this thesis, we develop a sensitive, robust, accurate method to detect chemically-induced DNA damage by three therapeutic agents, cisplatin, psoralen and busulfan. The method uses fluorescence spectroscopy and fluorescent hairpin or molecular beacon probes in a hybridization assay for...
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Terbium fluorescence as a sensitive, inexpensive probe for UV-induced damage in nucleic acids
Download2013-01-01
El-Yazbi, Amira F., Loppnow, Glen R.
Much effort has been focused on developing methods for detecting damaged nucleic acids. However, almost all of the proposed methods consist of multi-step procedures, are limited, require expensive instruments, or suffer from a high level of interferences. In this paper, we present a novel simple,...