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Skip to Search Results- 1Bundle, David R.
- 1Evans, David H (Medical Microbiology and Immunology)
- 1Li, Michael (Department of Mathematical and Statistical Sciences)
- 1Li, Michael (Mathematical and Statistical Sciences)
- 1Power, Christopher (Division of Neurology, Department of Medicine)
- 1Power, Christopher (Medicine, Division of Neurology)
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Mathematical modeling of HIV-1 therapeutic initiatives: shock and kill strategy in the brain and the natural control of the virus in the plasma
DownloadSpring 2024
This thesis is based on four main studies. The first two studies present a detailed methodology for completing dynamical system parameter estimation using Bayesian inference. The next two studies are about using this methodology to investigate critical human immunodeficiency virus-1 therapeutic...
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Fall 2016
Understanding human immunodeficiency-1 (HIV-1) replication and latency in different reservoirs is an ongoing challenge in the care of patients with HIV/AIDS. A mathematical model was created that predicted HIV-1 and simian immunodeficiency virus (SIV) infection dynamics within the brain during...
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Spring 2013
Glycans are a diverse and integral component of all biological organisms, making them an ideal target for vaccine development. Carbohydrates often act as weak antigens, lacking the T cell epitopes required to recruit T cell help which is vital to develop a strong and long lasting protective...
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The mechanism of action of cidofovir and (S)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine against viral polymerases
DownloadFall 2009
The nucleoside phosphonates cidofovir (CDV) and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine [(S)-HPMPA] are analogs of dCMP and dAMP, respectively. Collectively these drugs are effective inhibitors of a wide range of DNA viruses, RNA viruses, and retroviruses. Because they are nucleotide...