Search
Skip to Search Results- 5Drug delivery systems
- 5Gene therapy
- 2Transfection
- 1Adenovirus
- 1Antithrombotic polymers
- 1Cancer--Gene therapy
- 1Hsu, Charlie Yu Ming
- 1Kwok, Kun-Yu.
- 1Mehra, Tarun.
- 1Meneksedag Erol, Deniz
- 1Miklavcic, John
- 1Morin, Kevin Wayne.
- 3Faculty of Pharmacy and Pharmaceutical Sciences
- 2Department of Biomedical Engineering
- 1Department of Agricultural, Food and Nutritional Science
- 1Department of Chemical Engineering
- 1Department of Chemical and Materials Engineering
- 1Department of Chemistry
-
A Combined Computational and Experimental Investigation of Polynucleotide Binding Polymers for Therapeutic Applications
DownloadFall 2017
Polynucleotide binding polymers have a wide range of therapeutic applications including delivery systems for therapeutic polynucleotides, and antithrombotic drugs for extracellular nucleic acid-mediated thrombogenic events. This dissertation explores polynucleotide binding polymers in these two...
-
Ganglioside Increases Metastatic Potential and Susceptibility of Prostate Cancer to Gene Therapy in vitro
DownloadFall 2009
Prostate cancer (CaP) is the 2nd most common cancer in North American men. Tumour management strategies are appropriate for early stage disease, but advanced disease has a poor prognosis and requires prompt treatment. Therefore, research into delay of tumour progression and efficacious treatment...
-
Mechanistic studies on the uptake and intracellular trafficking of DNA complexes in primary cells using lipid-modified cationic polymers as non-viral gene carrier
DownloadFall 2012
This thesis work is aimed at addressing some of the fundamental questions surrounding the intracellular fate of plasmid DNA in clinically-relevant primary cells, when delivered with lipid-modi!ed cationic polymers as gene carriers. We developed an optimized procedure for the transfection of...
-
Stimuli-Responsive Microgel-Based Materials and Their Assembly for Controlled Drug Delivery and Sensing Systems
DownloadFall 2020
Conventional drug delivery methods result in a burst of drug concentration in plasma, followed by a decline, which leads to issues with maintaining drug concentrations in the therapeutic range. Furthermore, this high plasma concentration can lead to undesirable (and dangerous) side effects that...