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Skip to Search Results- 2Dekkers, Jack C. M.
- 2Harding, John C. S.
- 2PigGen Canada
- 2Plastow, Graham S.
- 1Alam, Shomoita
- 1Ashley, Carolyn
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Fall 2019
Rutabaga (Brassica napus ssp. napobrassica (L.) Hanelt) is widely grown as a vegetable crop and animal fodder, and is reported to be an excellent source of clubroot (Plasmodiophora brassicae) resistance genes. In this study, the genetic diversity and clubroot resistance of 124 rutabaga accessions...
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Spring 2012
Recent advances in high-throughput technologies, such as genome-wide SNP analysis and microar- ray gene expression profiling, have led to a multitude of ranked lists, where the features (SNPs, genes) are sorted based on their individual correlation with a phenotype. Multiple reviews have shown...
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Fall 2023
Given the roles of roots in water and nutrient uptake, anchorage, and storage of resources, root system architecture (RSA) can have a major impact on plant growth and development. The root systems of Brassica species, an important group that includes many field and horticultural crops, is...
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Spring 2015
Advance in biotechnologies has enabled genome-wide association studies (GWAS) that scan the entire human genome for understanding genetic contributions to the risk of a certain disease as well as to variation in treatment efficacy and side effects. In GWAS, the association between each...
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Factors Influencing Verticillium Stripe in Canola: Blackleg Interaction, Host Resistance, and pH
DownloadFall 2024
Verticillium stripe, caused by Verticillium longisporum, is emerging as an important disease of canola (Brassica napus) in Canada. This thesis aimed to enhance understanding of potential interactions between Verticillium stripe and blackleg (Leptosphaeria maculans), assess the influence of pH on...
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Fall 2019
The development of efficacious anticancer therapies has significantly improved the prognosis of childhood cancer patients at the price of predisposing survivors to extensive chronic health problems. Although not fatal, reducing treatment-related hearing loss (ototoxicity) among childhood cancer...
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Genomic Analysis of IgG Antibody Response to Common Pathogens in Commercial Sows in Health-Challenged Herds
Download2020-10-23
Sanglard, Leticia P., PigGen Canada, Mote, Benny E., Willson, Philip, Harding, John C. S., Plastow, Graham S., Dekkers, Jack C. M., Serao, Nick V. L.
Losses due to infectious diseases are one of the main factors affecting productivity in the swine industry, motivating the investigation of disease resilience-related traits for genetic selection. However, these traits are not expected to be expressed in the nucleus herds, where selection is...
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Identification and Characterization of a Novel Premenopausal Breast Cancer Locus and Insights into Copy Number Variations for Disease Predisposition and Prognosis
DownloadFall 2018
Breast cancer is a complex multifactorial disease with the interplay of genetic, environmental and lifestyle factors contributing to the disease risk. Studies based on twins estimated that ~30% of the risk is due to genetic factors. High and moderate penetrant mutations along with low penetrance...
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Identification of Shared and Distinct Gene-disease Associations Among Multiple Related Diseases and Multiple Subtypes of a Disease
DownloadFall 2013
Genome-wide association study (GWAS) is an approach with high-throughput genotyping to uncover genetic susceptibilities of complex diseases. However, the genetic susceptibilities discovered usually carry very small risk increments. Additionally, the current approach to assess whether these...
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Spring 2017
Introduction: Genome wide association studies (GWAS) have been widely used in recent years to identify the new information on genetic variants which are associated with complex trait in many diseases. Advances in identifying the Single nucleotide polymorphisms (SNPs) facilitate the study of...