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- 1APP and Aβ metabolism
- 1Alb-uPA/SCID/Beige mouse
- 1Alzheimer's disease
- 1Autotaxin inhibition
- 1Breast cancer
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Fall 2009
The feasibility of the Alb-uPA/SCID/Bg chimeric mouse as a model for Hepatitis C Virus (HCV) infection was assessed experimentally by (1) the infection and treatment with another hepatotropic virus, Hepatitis B Virus (HBV) and (2) the infection of the model with HCV and the subsequent treatment...
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Application of ROC curve analysis to metabolomics data sets for the detection of cancer in a mouse model
DownloadFall 2010
The goal of this study was to show that quantifiable metabolic changes may be used to screen for cancer. NIH III nude mice (n=22) were injected with human GBM cells, with daily urine samples collected pre and post-injection. 14 mice were injected with saline to serve as controls. The...
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Spring 2015
Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate from lysophosphatidylcholine, the most abundant phospholipid in plasma. Lysophosphatidate mediates many physiological and pathological processes by signaling through six G-protein-coupled receptors to promote...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Short-chain fatty acids influence host immunity, mucus secretion and microbial community structure to reduce enteritis
DownloadFall 2016
Optimal intestinal health is critical to overall host well-being, and acute and chronic enteric inflammatory diseases impart a significant detrimental impact on Canadians. The consumption of dietary fibre (DF) has long been associated with providing a health benefit to individuals, and regulatory...
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Thinking inside and outside the blood vessel: S1P-mediated control of vascular tone and the impact of CMV infection
DownloadSpring 2016
Sphingosine 1–phosphate (S1P), a bioactive lipid, has both endothelial barrier enhancing and disrupting effects, but also regulates vascular tone. The concepts of endothelial permeability and vascular tone have traditionally been studied separately. In this thesis, I demonstrate novel findings...