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Spring 2021
The electrocardiogram is the standard tool for detecting cardiac abnormalities, such as atrial fibrillation, irregular complexes, and heart blocks. However, the interpretation of this data is an unsolved problem with discrepancies among panels of cardiologists and automated analysis requiring...
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Fall 2022
Cardiovascular diseases are the leading cause of death globally, causing nearly 17.9 million deaths per year. Early detection and treatment are critical for improving this situation. Today's wearable medical devices are becoming popular because of their price and ease of use. Many manufacturers...
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Spring 2023
The electrocardiogram (ECG) records the electrical activity of a patient’s heart movement. It is one of the standard routine healthcare tests as it is non-invasive and easy to apply. In this thesis, we analyze 2 million ECGs and over 260,000 patients’ health records from the Alberta Health...
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The effects of hyperlipidemia on the pharmacokinetic and pharmacodynamic aspects of amiodarone and ketoconazole
DownloadFall 2010
The influence of hyperlipidemia on the pharmacodynamic and pharmacokinetic aspects of lipophilic drugs was explored. The antiarrhythmic, amiodarone, and the antifungal, (±)-ketoconazole, were used as model drugs. Experimental hyperlipidemia was induced in rat using poloxamer 407 and two sensitive...