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Skip to Search Results- 4Doxycycline
- 2Matrix Metalloproteinase
- 1Autotaxin
- 1Cardiomyocyte Injury
- 1Chemokine Receptors
- 1Chemokines
- 2Schulz, Richard
- 1Brindley, David N.
- 1Ceron, Carla S.
- 1Costa, Guilherme de Paula
- 1Curtis, Jonathan M.
- 1Dewald, Jay
- 2Medicine and Dentistry, Faculty of
- 2Medicine and Dentistry, Faculty of/Journal Articles (Medicine and Dentistry)
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Graduate and Postdoctoral Studies (GPS), Faculty of
- 1Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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Doxycycline and benznidazole reduce the profile of Th1, Th2, and Th17 chemokines and chemokine receptors in cardiac tissue from chronic Trypanosoma cruzi-infected dogs
Download2016-01-01
Costa, Guilherme de Paula, Lopes, Laís Roquete, Silva, Maria Cláudia da, Horta, Aline Luciano, Pontes, Washington Martins, Milanezi, Cristiane M., Schulz, Richard, Talvani, Andre
Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into cardiac tissue infected by the Trypanosoma cruzi. This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or not, with benznidazole (Bz) on the expression of...
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Matrix metalloproteinase inhibition attenuates right ventricular dysfunction and improves responses to dobutamine during acute pulmonary thromboembolism
Download2013-01-01
Neto‐Neves, Evandro M., Sousa‐Santos, Ozelia, Ferraz, Karina C., Rizzi, Elen, Ceron, Carla S., Romano, Minna M., Schulz, Richard, Tanus‐Santos, Jose E.
Activated matrix metalloproteinases (MMPs) cause cardiomyocyte injury during acute pulmonary thromboembolism (APT). However, the functional consequences of this alteration are not known. We examined whether doxycycline (a MMP inhibitor) improves right ventricle function and the cardiac responses...
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Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate
Download2016-01-01
Tang, Xiaoyun, Zhao, Yuan Y., Dewald, Jay, Curtis, Jonathan M., Brindley, David N.
Extracellular lysophosphatidate and sphingosine 1-phosphate (S1P) are important bioactive lipids, which signal through G-protein-coupled receptors to stimulate cell growth and survival. The lysophosphatidate and S1P signals are terminated partly by degradation through three broad-specificity...
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Fall 2013
Asphyxia is a significant cause of newborn morbidity and mortality. Multiorgan injury and dysfunction is a common finding, mediated in part through an increase in matrix metalloproteinase (MMP) activity. We hypothesized administration of doxycycline, a known MMP inhibitor, would improve systemic...