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Fall 2018

Perri, Melissa

Background Worldwide, body surface area [BSA] is used to calculate chemotherapy dose. The BSA formula was originally developed in 1916, derived from height and weight, with no consideration of other patient characteristics. Most chemotherapy agents have a narrow therapeutic index and are...

Fall 2011

Pant, Asha

This study determined how chemotherapy treatment for colorectal cancer alters hepatic fat metabolism. Livers were isolated from tumor-bearing animals after one and two cycles of chemotherapy consisting of irinotecan plus 5-fluorouracil. Fatty acid amounts and composition within triglycerides (TG)...

2011

Willing, Benjamin P., Finlay, B. Brett , Thanachayanont, Teerawat, Croxen, Matthew, Vacharaksa, Anjalee

Host resistance to bacterial infections is thought to be dictated by host genetic factors. Infections by the natural murine enteric pathogen Citrobacter rodentium (used as a model of human enteropathogenic and enterohaemorrhagic E. coli infections) vary between mice strains, from mild...

2013

Selinger, L. Brent, Inglis, G. Douglas, Uwiera, Richard R. E., Lone, Abdul, Xu, Yong

Background Campylobacter jejuni causes enterocolitis in humans, but does not incite disease in asymptomatic carrier animals. To survive in the intestine, C. jejuni must successfully compete with the microbiota and overcome the host immune defense. Campylobacter jejuni colonization success varies...

2017-01-06

Bording-Jorgensen, M. , O'keefe, S. , Mason, A., Warren, K., Patterson J., Jovel, J., Wong, G., Wang, W.

Multiple sclerosis (MS) is a common cause of non-traumatic neurologic disability with high incidence in many developed countries. Although the etiology of the disease remains elusive, it is thought to entail genetic and environmental causes, and microbial pathogens have also been envisioned as...

Spring 2024

Weyant, Robert Benson

Background: The Human Microbiome is an area of increasing interest, both in and outside of the scientific community. While overall knowledge has increased exponentially, many aspects remain unclear, such as mechanisms of host-interaction and persistence. Intracellular bacteria have previously...

2014

Koleva, Petya, Ketabi, Ali, Dieleman, Levinus A., Gänzle, Michael G., Valcheva, Rosica

Non-digestible oligosaccharides (NDO) were shown to reduce inflammation in experimental colitis, but it remains unclear whether microbiota changes mediate their colitis-modulating effects. This study assessed intestinal microbiota and intestinal inflammation after feeding chemically defined...

Fall 2010

Crisp, Nicole

Escalating cancer rates and an increase in the complexity and duration of chemotherapy regimens have brought the issue of cancer treatment at home to the forefront. For the participants of this study, home chemotherapy was offered as a potential treatment choice. Ten patients who accepted were...

Spring 2015

Hewitt, Joanne D

Despite the research to date, the characteristics and impact of cognitive dysfunction (CD) in cancer patients following chemotherapy is still not well understood. It is estimated approximately 20% of patients will manifest measurable cognitive deficits on neuropsychological testing...

Fall 2015

Ayoub, Ahmed T

Microtubules are cellular structures that are crucial to many cellular functions including maintenance of cell shape, vesicular transport, and cell division. The dynamic instability of microtubules is the basic feature which enables them to do their cellular functions. Their pivotal role in cell...