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- 1Abdulsalam Alharbi
- 1Aktary, Zackie M
- 1Alolayan, Waad Riyad
- 1Alshamsan, Aws
- 1Amritpal Singh Bhullar
- 1Armanious, Hanan A R
- 4Department of Oncology
- 1Department of Agricultural, Food, and Nutritional Science
- 1Department of Medicine
- 1Faculty of Kinesiology, Sport, and Recreation
- 1Faculty of Nursing
- 1Faculty of Rehabilitation Medicine
Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma ReceptorsDownload
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
Background Head and neck cancer treatments have been showing promising outcomes, yet they often have significant impact on patients. With an approximate 50% survival rate, individuals with a history of this type of cancer are living with long term challenges. With the increasing focus on...
Polycomb protein methyltransferase, Enhancer of Zeste 2 (Ezh2), is frequently overexpressed in human malignancy and is implicated in cancer cell proliferation and invasion. Recently, several other polycomb proteins have been implicated in modulating the response to DNA double strand breaks, and...
DNA is a detailed layout of instructions for cellular function. The integrity of human DNA is constantly challenged by a barrage of exogenous and endogenous sources. A regime of genome stability maintenance has evolved to repair the many different types of DNA damage. A form of communication...
Adiposity and fat loss in cancer: Exploring the prognostic significance and underlying mechanisms of adipose alterations in cancerDownload
During cancer progression, many patients will experience some degree of wasting of both muscle and adipose tissue. However, little is-known about adipose tissue alterations after a cancer diagnosis. Therefore, this research was conducted to first understand the prognostic significance of adipose...
Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of ResistanceDownload
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
There is substantial evidence of the elevated risk of cancer among individuals with type 2 diabetes. Very little is known, however, about the role that antidiabetic therapies play in this relationship. The objective of this program of research was to examine whether there is a therapeutic risk...
Application of ROC curve analysis to metabolomics data sets for the detection of cancer in a mouse modelDownload
The goal of this study was to show that quantifiable metabolic changes may be used to screen for cancer. NIH III nude mice (n=22) were injected with human GBM cells, with daily urine samples collected pre and post-injection. 14 mice were injected with saline to serve as controls. The...
Around the world, cancer is a leading cause of death and the burden of cancer is expected to increase in low-and middle-income countries (LMICs), where 82% of the world’s population resides. In these countries, which include Pakistan, aspects of the culture and traditions, inaccessibility to...
ABSTRACT Wnt signalling is of great biological importance as it has been implicated in development and cancer. The Wnt canonical pathway (WCP) is the best characterized signalling pathway. Based on my preliminary studies in my first and second years I found that the WCP is not linear and that it...