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Skip to Search Results- 1Ahrari, Malema
- 1Froentjes, Liesbeth
- 1Goplen, Craig M
- 1Kantor, Chase M
- 1Kerridge, Teresa A.
- 1Kokate, Tushar G.
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Antagonistic modulation of spontaneous neural network activities in isolated newborn rat brainstem preparations by opioids and methylxanthines
DownloadFall 2012
Apnea of prematurity is a common problem among the infants born before term pregnancy. Administration of respiratory stimulating drugs methylxanthines is the most frequent therapy, often in combination with the use of intubation. Opioids are used to reduce the pain associated with intubation,...
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Calcium Imaging and Field Potential Analysis of Autocrine Neuromodulation in the Locus Coeruleus of Newborn Rat Brain Slices
DownloadFall 2022
The locus coeruleus (LC) is a small brainstem nucleus that controls diverse behaviours and brain functions via release of noradrenaline (NA) in the neonatal time period. There is increasing evidence of complexity in this neuron-astrocyte ‘neural’ network that remains mostly unexplored in...
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Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: A systematic review
DownloadSpring 2012
Opioid-induced constipation (OIC) is an unpleasant and ubiquitous side effect of opioid treatment. Ineffective treatment of OIC can result in decreased adherence to opioid therapy, decreased quality of life, and increased morbidity and mortality. The constipating effects of opioids result from...
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Modulation of Spontaneous Neural Network Bursting in Newborn Rat Brain Slices by Extracellular Calcium, Methylxanthines, and Opioids
DownloadFall 2012
Spontaneous neuronal bursting appears to be pivotal for brain maturation. This thesis studied such synchronized neural network oscillations in immature newborn rat hippocampus, cortex, and locus coeruleus. For this, horizontal brain slices were generated for (simultaneous) suction electrode...
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Nonmedical Use of Opioids Following Short Term Therapeutic Exposure in Children and Youth: A Systematic Review and Qualitative Study of Decision Maker Information Needs
DownloadFall 2021
Introduction Healthcare visits, hospitalizations, and deaths due to opioid-related harms continue to rise for children, despite an overall decline in opioid prescriptions. Decision-makers (including patients, families, clinicians, and policy-makers) require high quality syntheses to inform...
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Fall 2019
Background: Up to 40% of patients are prescribed opioids prior to total knee arthroplasty (TKA) in the USA. These patients prescribed preoperative opioids have increased complications and worse outcomes after surgery. But, the impact of preoperative opioid use on patient-reported outcome (PRO)...
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Short, Intermediate, and Long-Term Effects of Opioids on Pain Intensity in Patients with Osteoarthritis or Low Back Pain: A Systematic Review and Meta-Analysis
DownloadFall 2020
Chronic opioid use is associated with the development of hyperalgesia, which may end up attenuating any analgesic benefits over long-term therapy. We wanted to determine whether the analgesic efficacy of opioids compared to control therapy for osteoarthritis and chronic lower back pain differed...