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An investigation of factors that regulate cytoskeleton in the first mitotic division of the C. elegans embryo
DownloadFall 2017
Microtubule dynamics is regulated by naturally occurring microtubule-associated proteins occurring in the cellular environment as well as by natural and synthetic compounds. These compounds target the microtubule cytoskeleton and serve as anti-mitotic drugs. Therefore, microtubules continue to be...
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Spring 2013
In the newly fertilized embryo, meiotic and mitotic spindles form consecutively within the same egg cytoplasm. The order of events during this transition is controlled, in part, via the regulation of the microtubule cytoskeleton. Herein, I show that mel-43 is part of a small paralogous gene...
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Spring 2016
Meiosis in eukaryotes includes a developmentally programmed pre-meiotic G2 phase arrest before the onset of MI division mediated by inhibitory phosphorylation of Cdk1. There are two inhibitory kinases, Wee1 and Myt1. Myt1 mediated Cyclin B-Cdk1 regulation serves as a conserved mechanism for...
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Mapping and characterization of mel-43(sb41), a gene required for early embryonic viability in C. elegans
DownloadSpring 2010
A genetic screen for dominant, temperature-sensitive, maternal-effect embryonic lethal mutations identified mel-43(sb41), a gene required for early embryonic viability (Mitenko et al., 1997). Linkage mapping placed mel-43 within a small region on chromosome IV. Genetic analyses suggested that...