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Subject: Brain fatty acid-binding protein Subject: FABP7 Collections: Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations

  • Mechanistic Insight Into the Role of FABP7 in Malignant Glioma

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    Fall 2012

    Beaulieu, Michael J.

    Malignant gliomas (MG) are the most common and aggressive brain cancers. FABP7 is an intracellular lipid trafficking molecule whose expression correlates with reduced MG patient survival. FABP7 has been shown to increase the migratory behaviour of MG cells. Moreover, the migratory behaviour of...

  • Nuclear Factor I in Malignant Glioma

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    Fall 2015

    Brun, Miranda

    Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...

  • Role of FABP7 and DHA in Glioblastoma Cell Migration

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    Fall 2021

    Xu, Xia

    Glioblastoma (GBM) is the most common primary brain malignancy and has a dismal prognosis. Despite advanced therapies, including surgery and concurrent radiotherapy with temozolomide (TMZ), GBM patients only have a 14.6-month median survival time. This dismal outcome can be attributed to the...

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