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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Casey, Geoffrey A
- 1Coulombe, Marilyne G.
- 1Forbrich, Alexander E
- 1Gavina, Kenneth C
- 1Goldansaz, Seyed Ali
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Identification of biomarkers associated with the onset and progression of ketosis in transition dairy cows
DownloadFall 2016
Ketosis is a common metabolic disorder of transition dairy cows during the early lactation period. Cows with ketosis have lower milk yield and reproductive performance, greater risk of other periparturient diseases, and higher culling rate. Although ketosis has been extensively studied, not many...
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Innate Immunity and the Retinal Pigment Epithelium in Gene Therapy for Inherited Retinal Disorders
DownloadFall 2021
Background: The photoreceptors are post-mitotic (no longer dividing), so the eye has evolved several unique immunological mechanisms to protect the photoreceptors and prevent vision loss. Inherited retinal disorders occur when mutations disrupt normal retinal function and photoreceptors die....
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Fall 2015
Despite considerable research progress towards characterizing the neurobiology of anxiety, the focus on putative behavioral markers and the absence of a common behavioural/neurobiological signature for the different classes of anxiolytic drugs have potentially slowed research into the neural...
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Spring 2018
The presence of natural oil seeps, abandoned well sites (generally containing light oil), and high quality source rocks along the coast of western Newfoundland has refocused interest on the region as an area for potential petroleum exploration and development. Most of the oil seeps and old well...
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Putative ante-mortem indicators of Alzheimer’s dementia: Analysis of fluid biomarker and neuroimaging studies
DownloadSpring 2019
Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...
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Quantitative Label-Free Comparative Proteomic Analyses of Eukaryotic Tissues via Mass Spectrometry
DownloadFall 2018
In recent years, rapid advances in genomic and transcriptomic sequencing technologies have enabled the compilation of vast libraries of protein sequences and thus an explosion in bioinformatics-based fields of research. Among these is proteomics – the study of global protein abundance within a...
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Fall 2016
Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer’s disease (AD) and preclinical cognitive and memory decline in older adults. We investigated whether memory resilience to genetic risk (i.e., Apolipoprotein E [APOE] ɛ4, Clusterin [CLU] CC, and a high additive...
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Spring 2023
Glycosylation is the enzymatic modification of biomacromolecules (proteins, etc.) with carbohydrates known as glycans. Naturally occurring in all organisms from viruses to animals, glycans have multifaceted functions in all aspects of biology. Aberrant glycosylation is often observed in diseases...
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The Role of Haemocytes in the Immune Response of Biomphalaria glabrata against Schistosoma mansoni: Investigations into Haematopoiesis and Pattern Recognition Receptors
DownloadSpring 2018
Snails (Gastropoda) serve as hosts for the larval development of many medically and agriculturally important digenean trematodes (parasitic flatworms), including schistosomes, blood flukes that collectively infect more than 260 million people globally. Compatibility between snails and digeneans...